Adult Hippocampal Neurogenesis in Mammals (and Humans): The Death of a Central Dogma in Neuroscience and its Replacement by a New Dogma
| Autor: | Ronald W. Oppenheim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mammals Neurons Neurogenesis Context (language use) Hippocampal formation Biology Hippocampus 03 medical and health sciences Cellular and Molecular Neuroscience Critical appraisal 030104 developmental biology 0302 clinical medicine Behavioral test Developmental Neuroscience Species Specificity Animals Humans Neuroscience 030217 neurology & neurosurgery Cell Proliferation |
| Zdroj: | Developmental neurobiology. 79(3) |
| ISSN: | 1932-846X |
| Popis: | The review is a critical appraisal of the history and present status of the phenomenon of adult hippocampal neurogenesis (AHN) in the mammalian and human brain. Previous as well as most current studies of AHN have focused on highly inbred domestic mice and rats that are examined in rigorously controlled laboratory environments using psychology-based behavioral tests. However, this approach cannot reveal the adaptive significance of AHN, a key unresolved question in the field. After the publication of several thousand articles in the field over the last 20 years, little progress has been made in our understanding of the biological utility of AHN in the real world. To accomplish this will require comparative studies employing a greater diversity of species and species-specific behaviors that are investigated in a more naturalistic, evolutionary context. Although efforts along these lines are on the rise, they remain "voices in the wilderness." This review is an attempt to hasten and increase those efforts. |
| Databáze: | OpenAIRE |
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