Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles
| Autor: | Supang Khondee, Thomas D. Wang, Zhen Qiu, Emily F. Rabinsky, Lili Zhao, Bishnu P. Joshi, Scott R. Owens, Xiyu Duan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adenoma
Lithocholic acid medicine.medical_treatment Chemistry Pharmaceutical Intraperitoneal injection Pharmaceutical Science Peptide Pharmacology Micelle Binding Competitive Article Targeted therapy Polyethylene Glycols chemistry.chemical_compound Mice Drug Delivery Systems In vivo Cell Line Tumor medicine Animals Humans Micelles beta Catenin chemistry.chemical_classification Sirolimus Antibiotics Antineoplastic Chemistry medicine.disease Lithocholic Acid Colorectal Neoplasms Peptides medicine.drug |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 199 |
| ISSN: | 1873-4995 |
| Popis: | Many powerful drugs have limited clinical utility because of poor water solubility and high systemic toxicity. Here, we formulated a targeted nanomedicine, rapamycin encapsulated in pegylated octadecyl lithocholate micelles labeled with a new ligand for colorectal neoplasia, LTTHYKL peptide. CPC;Apc mice that spontaneously develop colonic adenomas were treated with free rapamycin, plain rapamycin micelles, and peptide-labeled rapamycin micelles via intraperitoneal injection for 35 days. Endoscopy was performed to monitor adenoma regression in vivo. We observed complete adenoma regression at the end of therapy. The mean regression rate for peptide-labeled rapamycin micelles was significantly greater than that for plain rapamycin micelles, P |
| Databáze: | OpenAIRE |
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