Analysis of the Relationships between Multiple Endocrine Hormones and Return of Spontaneous Circulation (ROSC) in Cardiac Arrest Patients: Possible Association of the Serum Free T4 Level with ROSC

Autor:	Toru Iizaka, Yasuyoshi Kigawa, Ryo Saiki, Fumiko Otsuka, Mariko Kaji, Munetaka Hayashi, Jun Sasaki, Kei Endo, Shoichiro Nagasaka, Tatsuya Iida, Kentaro Mikura, Mai Hashizume, Norimitsu Murai, Go Koizumi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism 030204 cardiovascular system & hematology Return of spontaneous circulation Plasma renin activity Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Anterior pituitary Internal medicine medicine Endocrine system 030212 general & internal medicine Aldosterone Endocrine and Autonomic Systems business.industry Thyroid RC648-665 medicine.anatomical_structure chemistry Shock (circulatory) medicine.symptom business Research Article Hormone
Zdroj:	International Journal of Endocrinology, Vol 2020 (2020) International Journal of Endocrinology
ISSN:	1687-8337
DOI:	10.1155/2020/4168420
Popis:	Background. Endocrine hormones are closely associated with homeostasis, so it is important to clarify hormone secretion dynamics in shock. Few reports, however, have examined the dynamics of endogenous hormone secretion relative to prognosis in cardiac arrest patients. Therefore, to clarify the roles of endocrine hormones in out-of-hospital cardiac arrest (OHCA) patients, the concentrations of anterior pituitary, thyroid, and adrenocortical hormones were measured, and their associations with return of spontaneous circulation (ROSC) were examined. Methods. The subjects were OHCA patients transported to our Emergency Department. In addition to conventional clinical laboratory tests, the following were measured: serum TSH, serum free T3, serum free T4 (F-T4), plasma ACTH, serum cortisol, serum GH, serum IGF-1, plasma aldosterone concentration (PAC), and plasma renin activity. The primary endpoint was the presence or absence of ROSC, and the secondary endpoint was 24-hour survival. Results. A total of 29 patients, 17 in the ROSC group and 12 in the non-ROSC group, were studied. There were associations between ROSC and low serum potassium, high F-T4, low cortisol, and low PAC on bivariate analyses. There were associations between ROSC and serum potassium, F-T4, and GH using the step-wise method. On multiple logistic regression analysis, a relationship between ROSC and high serum F-T4 level was identified by both methods. There were also associations between 24-hour survival and both low serum potassium and elevated blood glucose levels. Conclusions. The present findings suggest a possible relationship between the serum F-T4 level and ROSC in OHCA patients. A higher serum F-T4 level might cause an increase in the β-adrenergic response in cardiomyocytes and increased responsiveness to catecholamines and was possibly associated with ROSC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd72bac051afc5f12cf74e19f4bfa9a Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.