Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models
| Autor: | Carlotta Marianecci, M. Mastriota, Federica Rinaldi, Stefano Pieretti, Maria Carafa, Donatella Paolino, Elena Trapasso |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
Adult Keratinocytes Male Skin erythema medicine.drug_class Cell Survival media_common.quotation_subject Skin Absorption Anti-Inflammatory Agents Pharmaceutical Science Mice Inbred Strains Pharmacology In Vitro Techniques Administration Cutaneous Anti-inflammatory Cell Line Mice Drug Delivery Systems In vivo medicine Animals Edema Humans Niosome Cytotoxicity media_common Pain Measurement Skin Liposome ammonium glycyrrhizinate inflammation niosomes skin tolerability toxicity Molecular Structure Chemistry Glycyrrhizic Acid Tolerability Erythema Liposomes |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 164(1) |
| ISSN: | 1873-4995 |
| Popis: | Today there is a very great deal of interest among members of the global natural products community in investigating new plant constituents. Recent studies demonstrate that liquorice extracts are useful in the treatment of dermatitis, eczema, and psoriasis, with an efficacy comparable to that of corticosteroids. In this work, niosomes made up of surfactants (Tween 85 and Span 20) and cholesterol at various concentrations were prepared to investigate the potential application of niosomes for the delivery of ammonium glycyrrhizinate (AG), useful for the treatment of various inflammatory based diseases. Vesicles were characterized evaluating dimensions, ζ potential, anisotropy, drug entrapment efficiency, stability, cytotoxicity evaluation and skin tolerability. Release profiles of ammonium glycyrrhizinate/niosomes were evaluated in vitro using cellulose membranes. The best formulation was used to evaluate the in vitro/in vivo efficacy of the ammonium glycyrrhizinate/niosomes in murine and human models of inflammation. The AG-loaded non-ionic surfactant vesicles showed no toxicity, good skin tolerability and were able to improve the drug anti-inflammatory activity in mice. Furthermore, an improvement of the anti-inflammatory activity of the niosome delivered drug was observed on chemically induced skin erythema in humans. |
| Databáze: | OpenAIRE |
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