Effects of intravitreous sodium hydrosulfide on intraocular pressure and retinopathy in ocular hypertensive rats
| Autor: | Selçuk Takır, Serkan Ozen, Murat Atabey Özer, Zuleyha Erisgin, Yavuz Tekelioglu |
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| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı, Özer, Murat Atabey |
| Rok vydání: | 2017 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty Histology genetic structures medicine.medical_treatment Histopathology Glaucoma Ocular hypertension Apoptosis Sodium hydrosulfide Intravitreous Injection Sulfides digestive system Retina Vitreous 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Animals Hydrogen Sulfide Saline Intraocular Pressure business.industry General Medicine Reference Standards Flow Cytometry medicine.disease digestive system diseases eye diseases Rats Disease Models Animal Medical Laboratory Technology medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Administration Intravenous Ocular Hypertension sense organs business 030217 neurology & neurosurgery Laser Photocoagulation Retinopathy |
| Zdroj: | Biotechnic & Histochemistry. :1-7 |
| ISSN: | 1473-7760 1052-0295 |
| Popis: | Erisgin, Zuleyha/0000-0003-3523-6542 WOS: 000432534800002 PubMed: 29215307 We investigated the possible neuroprotectant and intraocular pressure (TOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling TOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week. For the NaSH group, rats were treated with intravenous NaSH 3 weeks after photocoagulation. IOP was measured each week during the 6 week experimental period. Coagulating the episcleral veins rapidly increased the IOP of rat eyes. Intravitreous injection of NaSH significantly reduced IOP. Intravitreous NaSH prevented degeneration of the retina and decreased the number of apoptotic cells. Intravitreous NaSH appeared to reduce IOP and to prevent IOP induced retinopathy in rats. |
| Databáze: | OpenAIRE |
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