| Autor: |
Margaret T. Mandelson, Brian M. Wolpin, Jay S. Wunder, Federico Canzian, Li Jiao, Joanne W. Elena, Beata Peplonska, Göran Hallmans, Nicolas Wentzensen, Edward Giovannucci, Elizabeth A. Holly, Chenwei Liu, Olaya Villa, Maria Feychting, Stephanie J. Weinstein, Mia M. Gaudet, Nilanjan Chatterjee, Margaret R. Spitz, Gilles Thomas, Lauren T. Teras, Dalsu Baris, Christian C. Abnet, Pier Alberto Bertazzi, William Wheeler, Ze Zhong Tang, Marie Josephe Horner, Caroline G. Epstein, Irene L. Andrulis, Zhaoming Wang, Woon-Puay Koh, David J. Hunter, Ulrike Peters, John K. Wiencke, Loic Le Marchand, Christian P. Kratz, Margaret Wrensch, Benjamin A. Rybicki, Robert R. McWilliams, Kay-Tee Khaw, Neil E. Caporaso, Jian-Min Yuan, Dimitrios Trichopoulos, Eric J. Duell, Manal M. Hassan, Michael Cullen, Julie E. Buring, Alison P. Klein, Michael B. Cook, Katherine A. McGlynn, Donghui Li, Juan R. González, Margaret A. Tucker, Andrea Z. LaCroix, Yu Tang Gao, Christopher A. Haiman, Curtis C. Harris, Graham G. Giles, Mark P. Purdue, William J. Blot, Ti Ding, Laurence N. Kolonel, Gianluca Severi, Ludmila Prokunina-Olsson, Christine D. Berg, Kala Visvanathan, Xiang Deng, J. Michael Gaziano, Melinda C. Aldrich, Philip R. Taylor, Peter D. Inskip, Meredith Yeager, Annelie Landgren, Rachael Z. Stolzenberg-Solomon, Montserrat Garcia-Closas, Demetrius Albanes, Sharon A. Savage, Sara H. Olson, Steven Gallinger, Lorna H. McNeill, Kendra Schwartz, Susan E. Hankinson, Krista A. Zanetti, Anne Tjønneland, Laurie Burdett, Francisco X. Real, Fredrick R. Schumacher, Herbert Yu, Victoria L. Stevens, Beatrice Melin, Paige M. Bracci, Melissa Rotunno, Charles Kooperberg, Joshua N. Sampson, Cathryn H. Bock, Preetha Rajaraman, Yong-Bing Xiang, Gloria M. Petersen, Xiao-Ou Shu, Joseph Kovaks, Dario Consonni, You-Lin Qiao, Lee E. Moore, Harvey A. Risch, Dominique S. Michaud, Peter Kraft, Louise A. Brinton, Vittorio Krogh, Michael Dean, Luis A. Pérez-Jurado, Linda M. Liao, Lynn R. Goldin, Christopher I. Amos, Wei Zheng, Alan A. Arslan, Faith G. Davis, Myron D. Gross, Robert N. Hoover, Mary Ann Butler, Anne Zeleniuch-Jacquotte, Ralph L. Erickson, Christoffer Johansen, Kevin B. Jacobs, Daniel O. Stram, Laufey T. Amundadottir, Elizabeth M. Gillanders, Debra T. Silverman, Manolis Kogevinas, Mark H. Greene, Weiyin Zhou, Wong Ho Chow, Patricia Hartge, Roberta McKean-Cowdin, Alisa M. Goldstein, Michelle Cotterchio, Núria Malats, Charles S. Fuchs, Kai Yu, Joseph F. Fraumeni, Roger Henriksson, Lisa B. Signorello, Nathaniel Rothman, Sholom Wacholder, Jarmo Virtamo, Julie B. Mendelsohn, Charles C. Chung, Nan Hu, Molly Schwenn, Gaëlle Marenne, Sonja I. Berndt, Laura E. Beane Freeman, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, Ana Patino Garcia, Howard D. Sesso, Amanda Black, Avima M. Ruder, Robert C. Kurtz, Donald A. Barkauskas, Jonine D. Figueroa, Ulrika Andersson, Kari G. Rabe, Tania Carreón, Barry I. Graubard, Anders Ahlbom, Regina G. Ziegler, Xifeng Wu, Jolanta Lissowska, Judith A. Hoffman Bolton, Benjamín Rodríguez-Santiago, Alison Johnson, Brian E. Henderson, Amy Hutchinson, Elio Riboli, Michael Goggins, Luis Sierrasesà maga, Geoffrey S. Tobias, Alicja Wolk, Lisa Mirabello, Jin-Hu Fan, Neal D. Freedman, Richard Gorlick, Kenneth J. Chang, Mazda Jenab, Ann G. Schwartz, Marie-Christine Boutron-Ruault, Ann W. Hsing, Maria Teresa Landi, Susan M. Gapstur, Emily White |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Nature Genetics; Vol 44
Nature genetics
Dipòsit Digital de la UB
Universidad de Barcelona
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname |
| Popis: |
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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