The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Autor: Torres Martí, Antoni, Motos, Anna, Riera, Jordi, Fernández Barat, Laia, Ceccato, Adrián, Pérez Arnal, Raquel, García Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez Oviedo, Alejandro, Gonzalo Calvo, David de, Casacuberta Barberà, Núria, Rubio, Jorge, Bodi Saera, María, Suares Sipmann, Fernando, Bofill, Neus, Bouza Vieiro, María Teresa, Bueno, Leticia, Pérez Bastida, Leire, Bustamante-munguira, Juan, López Lago, Ana, Yang, Minlan, Muñoz Bermúdez, Rosana, Cachafeiro, Lucia, Martín Vicente, Paula, Mañez Mendiluce, Rafael, Campi Hermoso, David, Castellà, Manuel, Serra, Lidia, Bustamante Munguira, Elena, Castellví, Andrea, Díaz, Yolanda, Figueras, Albert, Salazar Degracia, Ana, Gordo, Federico, Rivas Vilas, María Digna, Dólera Moreno, Cristina, Nicolás, José María, Rubio López, Alberto, Dot, Irene, García Sagastume, Amaia, Servià, Lluís, García, Beatriz, Urrelo Cerrón, Luis, Enríquez Giraudo, Pedro, Barral Segade, Patricia, Esmorís Arijón, Inés, Farre Monjo, Teresa, Pérez Planelles, Gloria, Segura Pensado, Marta, Fernández, Javier, Ruiz Miralles, Miriam, Gabarrús, Albert, Nogue Bou, Ramon, Prados, Javier, Ferrando, Carlos, Pérez Rubio, Eva, Vilà Vilardel, Clara, Ossa, Sergio, García Prieto, Emilio, Herraiz, Alba, Amaya Villar, Rosario, Bermejo Martín, Jesús F., Herrán Monge, Rubén, Ryan Murúa, Pablo, Val, Estela, Ibarz, Mercedes, Mantellini, Cecilia L., Yang, Hua, Macias Guerrero, Desire, Iglesias, Silvia, Janer, Maria Teresa, Jiménez, Gabriel, Serra Fortuny, Mireia, Vidal Cortes, Pablo, Juan Díaz, Mar, Valdivia Ruiz, Luis, Novo, Mariana Andrea, Saborido Paz, Eva, Barberán, José, Serrano Lázaro, Ainhoa, Santacoloma, Bitor, Mamolar Herrera, Nuria, Martínez Juan, Maria Dolores, Salvador Adell, Inmaculada, Pozo Laderas, Juan Carlos, Masa Jimenez, Juan Fernando, Vallverdú, Montserrat, Masclans, Joan Ramon, Moreno Cano, Sara Guadalupe, Martínez de la Gándara, Amalia, Piñol-tena, Àngels, Maseda, Emilio, Menor Fernández, Eva María, Vilanova, Judit, Huerta, Arturo, Miralbés, Mar, Parera Pous, Anna, Climent, Cristina, Socias, Lorenzo, Ocón, Marta, Aldecoa, César, Monclou, Josman, Gracia, Maria Pilar, Montejo González, Juan Carlos, Montserrat, Neus, Añón, José M., Ricart, Pilar, Mora Aznar, María, Van Der Hofstadt Martin-Montalvo, Maria, Jorge García, Ruth Noemí, Moral Parras, Pedro, Villada Warrington, Tatiana, Carbajales, Cristina, Morales, Dulce, Barberà, Carme, Mariño, Ana Balan, Almansa Mora, Raquel, Ortega, Ana, Pujol, Andrés, Ángel, José, Soliva, Laura, Ramon Coll, Núria, Renedo Sanchez-Giron, Gloria, Loza Vázquez, Ana, Alegre, Cynthia, Roche Campo, Ferran, Sariñena, Maria Teresa, Barbeta, Enric, Sanchez, Miguel, Rodriguez, Laura, Martínez Fernández, Carmen Eulalia, Rodríguez de Castro, Felipe, Rodríguez, Silvia, Sánchez Miralles, Angel, Báez Pravia, Orville, Rodríguez Ruiz, Covadonga, Álvarez, Sergio, Cicuendez Ávila, Ramon, Marin Corral, Judith, Blandino Ortiz, Aaron, Sancho Chinesta, Susana, Cantón-bulnes, Maria Luisa, Albaiceta, Guillermo M., Sánchez, Ana, Tognetti, Daniel, Codina, Jordi, Clar, Luisa, Tormos, Adrián, Álvarez Ruiz, Antonjo, Torres, Mateu, Vengoechea, Javier, Carvalho, Sula, Vara Adrio, Sabela, Caballero, Jesús, Trefler, Sandra, Trujillano, Javier, Balsera, Begoña, Cano, Iosune, Úbeda, Alejandro, Menéndez, Rosario, Andrea, Rut, Martin, María Cruz, Barbena, Laura, Badia, Joan Ramon, Vázquez, Nil, Zapatero, Ana, Gómez Casal, Vanesa, Gascón Castillo, Maria Luisa, CIBERESUCICOVID Project (COV20/00110, ISCIII), Carbonell, Nieves, Gómez, José M., García, Felipe, Solé Violan, Jordi, Catalán González, Mercedes, Galbán, Cristóbal, Cardina Fernández, Pablo, Forcadell Ferreres, Eva, Gumucio Sanguino, Víctor D., Peñasco, Yhivian, González, Jessica, Martínez Varela, Ignacio, Kiarostami, Karsa, Torre, Maria del Carmen de la, Speziale, Carla, Díaz Santos, Emili, Estella, Ángel, Conde, Pamela, Gomà, Gemma, Gallego, Elena, Forcelledo Espina, Lorena, García Garmendia, José Luis, Carrión García, Laura, Busto Martínez, Cecilia del, Garnacho Montero, José, Contreras, Sofía, Marcos, Pilar, Castro, Pedro, López Messa, Juan, Tamayo Lomas, Luis, Bardi, Tommaso, Trenado, José, Barbé, Ferran, Franco, Nieves, Lazo Álvarez, Juan I., Adell Serrano, Berta, Badía, Mariona, Martínez, María, Arrieta, Marta, Agrifoglio, Alexander, Aguilar Cabello, María, Aguilera, Luciano, Gómez, Silvia, Marco Naya, Gregorio, Alcaraz Serrano, Victoria, León, Miguel, Pagliarani, Pablo, Furro, Àngels, Pablo Sánchez, Raul de, Gómez Gonzalez, Carmen, García Redruello, Carlos, Ayestarán, J. Ignacio, Barroso, Marta, Pérez, Purificación, Parrilla, Francisco, Berezo García, José Ángel, López Gavín, Alexandre, Bigas, Judit, Campos Fernández, Sandra, Nogueras Salinas, Rafaela, Mendoza, Diego de, Blancas, Rafael, Blasco Cortés, María Luisa, Marmol Peis, Enrique, Mosquera Rodríguez, David, Boado, María, Cillóniz, Catia, Ferrer Roca, Ricard, Pestaña Laguna, David
Přispěvatelé: Institut Català de la Salut, [Torres A] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Institut d’Investigacions August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. Servei de Pneumologia i Al·lèrgia Respiratòria, Hospital Clínic, 08036 Barcelona, Spain. [Motos A, Fernández-Barat L] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Institut d’Investigacions August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. [Riera J, Ferrer R] Servei de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ceccato A] Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Pérez-Arnal R] Barcelona Supercomputing Center (BSC), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació
Rok vydání: 2021
Předmět:
Male
ARDS
medicine.medical_treatment
Enfermedad transmisible
terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
Respiració artificial
Critical Care and Intensive Care Medicine
COVID-19 (Malaltia)
Cohort Studies
chemistry.chemical_compound
COVID-19 (Disease)
Mechanical ventilation
Medicine
Intubation
Enfermedades pulmonares
Hospital Mortality
Prospective Studies
Prospective cohort study
Aged
80 and over
Respiratory Distress Syndrome
Medical emergencies. Critical care. Intensive care. First aid
Middle Aged
Prognosis
enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto [ENFERMEDADES]
Intensive Care Units
Artificial respiration
Anesthesia
Female
Cohort study
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]
Critical Care
Pronòstic mèdic
Prognosi
Infecciones por coronavirus
Ventilation/perfusion ratio
Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome
Adult [DISEASES]
Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration
Artificial [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
Ventilation-Perfusion Ratio
Humans
COVID-19 (Malaltia) - Espanya
Mortality
Diagnosis::Prognosis [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
Aged
Retrospective Studies
Creatinine
RC86-88.9
business.industry
SARS-CoV-2
Research
Correction
Ventilatory ratio
COVID-19
Retrospective cohort study
Aparato respiratorio
medicine.disease
Respiration
Artificial
Coronavirus
Meta-analysis
chemistry
Spain
Pulmonary Ventilation
business
Zdroj: CRITICAL CARE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Scientia
Critical Care
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Critical care (London, England)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Critical Care, Vol 25, Iss 1, Pp 1-13 (2021)
Scopus
Repositorio Abierto de la UdL
Universitad de Lleida
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
RUO. Repositorio Institucional de la Universidad de Oviedo
ISSN: 1364-8535
1466-609X
Popis: Following publication of the original article at https://doi.org/10.1186/s13054-021-03727-x the authors identified an error in the Funding section that has been corrected (https://doi.org/10.1186/s13054-021-03849-2)
Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.
Databáze: OpenAIRE
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