The two pore potassium channel THIK ‐1 regulates NLRP3 inflammasome activation

Autor:	Samuel Drinkall, Catherine B. Lawrence, Bernadino Ossola, Samuel Russell, Clare Bender, Nicola B. Brice, Lee A. Dawson, Michael Harte, David Brough
Rok vydání:	2022
Předmět:	Mice Knockout Potassium Channels Inflammasomes Caspase 1 Interleukin-1beta Mice Inbred C57BL Mice Cellular and Molecular Neuroscience Adenosine Triphosphate Potassium Channels Tandem Pore Domain Diabetes Mellitus Type 2 Neurology NLR Family Pyrin Domain-Containing 3 Protein Potassium Animals
Zdroj:	Glia. 70:1301-1316
ISSN:	1098-1136 0894-1491
Popis:	The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi-protein complex responsible for the activation of caspase-1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL-1β and IL-18, and pyroptotic cell death. NLRP3 is implicated as a driver of inflammation in a range of disorders including neurodegenerative diseases, type 2 diabetes, and atherosclerosis. A commonly reported mechanism contributing to NLRP3 inflammasome activation is potassium ion (K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd23d64a1806c65a4cb1a3005dd0914 https://doi.org/10.1002/glia.24174 Zobrazit plný text záznamu Plný text