Investigating expectation and reward in human opioid addiction with [(11) C]raclopride PET
Autor: | Ben Watson, L.G. Taylor, Sue Wilson, Jim Myers, Anne Lingford-Hughes, David J. Brooks, Federico Turkheimer, Paul R. A. Stokes, Alastair G. Reid, David J. Nutt |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
Dopamine Human Neuroimaging Studies Medicine (miscellaneous) Pharmacology Heroin 0302 clinical medicine VENTRAL STRIATUM media_common Raclopride PLACEBO Substance Abuse Middle Aged 3. Good health Buprenorphine Analgesics Opioid Psychiatry and Mental health Opiate Psychology Life Sciences & Biomedicine RECEPTOR-BINDING medicine.drug Adult Biochemistry & Molecular Biology CONTINUOUS-INFUSION INDUCED DOPAMINE RELEASE media_common.quotation_subject NUCLEUS-ACCUMBENS Addiction 03 medical and health sciences Young Adult POSITRON-EMISSION-TOMOGRAPHY Reward mental disorders medicine Humans OPIATE Aged Science & Technology ALCOHOL DEPENDENCE Anticipation Psychological Opioid-Related Disorders Corpus Striatum 030227 psychiatry PET Opioid Positron-Emission Tomography opioid Dopamine Antagonists COCAINE heroin 030217 neurology & neurosurgery Methadone expectation |
Zdroj: | Watson, B J, Taylor, L G, Reid, A G, Wilson, S J, Stokes, P R, Brooks, D J, Myers, J F, Turkheimer, F E, Nutt, D J & Lingford-Hughes, A R 2014, ' Investigating expectation and reward in human opioid addiction with [(11) C]raclopride PET ', Addiction Biology (Online), vol. 19, no. 6, pp. 1032-40 . https://doi.org/10.1111/adb.12073 Addiction Biology |
DOI: | 10.1111/adb.12073 |
Popis: | The rewarding properties of some abused drugs are thought to reside in their ability to increase striatal dopamine levels. Similar increases have been shown in response to expectation of a positive drug effect. The actions of opioid drugs on striatal dopamine release are less well characterized. We examined whether heroin and the expectation of heroin reward increases striatal dopamine levels in human opioid addiction. Ten opioid-dependent participants maintained on either methadone or buprenorphine underwent [(11) C]raclopride positron emission tomography imaging. Opioid-dependent participants were scanned three times, receiving reward from 50-mg intravenous heroin (diamorphine; pharmaceutical heroin) during the first scan to generate expectation of the same reward at the second scan, during which they only received 0.1-mg intravenous heroin. There was no heroin injection during the third scan. Intravenous 50-mg heroin during the first scan induced pronounced effects leading to high levels of expectation at the second scan. There was no detectable increase in striatal dopamine levels to either heroin reward or expectation of reward. We believe this is the first human study to examine whether expectation of heroin reward increases striatal dopamine levels in opioid addiction. The absence of detectable increased dopamine levels to both the expectation and delivery of a heroin-related reward may have been due to the impact of substitute medication. It does however contrast with the changes seen in abstinent stimulant users, suggesting that striatal dopamine release alone may not play such a pivotal role in opioid-maintained individuals. |
Databáze: | OpenAIRE |
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