Investigating expectation and reward in human opioid addiction with [(11) C]raclopride PET

Autor: Ben Watson, L.G. Taylor, Sue Wilson, Jim Myers, Anne Lingford-Hughes, David J. Brooks, Federico Turkheimer, Paul R. A. Stokes, Alastair G. Reid, David J. Nutt
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Dopamine
Human Neuroimaging Studies
Medicine (miscellaneous)
Pharmacology
Heroin
0302 clinical medicine
VENTRAL STRIATUM
media_common
Raclopride
PLACEBO
Substance Abuse
Middle Aged
3. Good health
Buprenorphine
Analgesics
Opioid

Psychiatry and Mental health
Opiate
Psychology
Life Sciences & Biomedicine
RECEPTOR-BINDING
medicine.drug
Adult
Biochemistry & Molecular Biology
CONTINUOUS-INFUSION
INDUCED DOPAMINE RELEASE
media_common.quotation_subject
NUCLEUS-ACCUMBENS
Addiction
03 medical and health sciences
Young Adult
POSITRON-EMISSION-TOMOGRAPHY
Reward
mental disorders
medicine
Humans
OPIATE
Aged
Science & Technology
ALCOHOL DEPENDENCE
Anticipation
Psychological

Opioid-Related Disorders
Corpus Striatum
030227 psychiatry
PET
Opioid
Positron-Emission Tomography
opioid
Dopamine Antagonists
COCAINE
heroin
030217 neurology & neurosurgery
Methadone
expectation
Zdroj: Watson, B J, Taylor, L G, Reid, A G, Wilson, S J, Stokes, P R, Brooks, D J, Myers, J F, Turkheimer, F E, Nutt, D J & Lingford-Hughes, A R 2014, ' Investigating expectation and reward in human opioid addiction with [(11) C]raclopride PET ', Addiction Biology (Online), vol. 19, no. 6, pp. 1032-40 . https://doi.org/10.1111/adb.12073
Addiction Biology
DOI: 10.1111/adb.12073
Popis: The rewarding properties of some abused drugs are thought to reside in their ability to increase striatal dopamine levels. Similar increases have been shown in response to expectation of a positive drug effect. The actions of opioid drugs on striatal dopamine release are less well characterized. We examined whether heroin and the expectation of heroin reward increases striatal dopamine levels in human opioid addiction. Ten opioid-dependent participants maintained on either methadone or buprenorphine underwent [(11) C]raclopride positron emission tomography imaging. Opioid-dependent participants were scanned three times, receiving reward from 50-mg intravenous heroin (diamorphine; pharmaceutical heroin) during the first scan to generate expectation of the same reward at the second scan, during which they only received 0.1-mg intravenous heroin. There was no heroin injection during the third scan. Intravenous 50-mg heroin during the first scan induced pronounced effects leading to high levels of expectation at the second scan. There was no detectable increase in striatal dopamine levels to either heroin reward or expectation of reward. We believe this is the first human study to examine whether expectation of heroin reward increases striatal dopamine levels in opioid addiction. The absence of detectable increased dopamine levels to both the expectation and delivery of a heroin-related reward may have been due to the impact of substitute medication. It does however contrast with the changes seen in abstinent stimulant users, suggesting that striatal dopamine release alone may not play such a pivotal role in opioid-maintained individuals.
Databáze: OpenAIRE