Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose
| Autor: | Amanda Marreiro Barbosa, Paola Miranda Sulis, Katia Motta, Alex Rafacho, Matheus Henrique Besen, Everson Araújo Nunes, Júlia Santos Silva |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Article Subject lcsh:Medicine 030209 endocrinology & metabolism Fructose Carbohydrate metabolism Biology General Biochemistry Genetics and Molecular Biology Eating 03 medical and health sciences chemistry.chemical_compound Fish Oils 0302 clinical medicine Animals Homeostasis Ingestion Water intake Food science Rats Wistar Cholesterol homeostasis General Immunology and Microbiology lcsh:R Lipid metabolism Feeding Behavior General Medicine Lipid Metabolism Fish oil Diet Rats Glucose 030104 developmental biology chemistry Dietary Supplements Research Article |
| Zdroj: | BioMed Research International, Vol 2017 (2017) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2017/4378328 |
| Popis: | Background.Continuous fructose consumption may cause elevation of circulating triacylglycerol. However, how much of this alteration is reverted after the removal of fructose intake is not known. We explored this question and compared the efficacy of this approach with fish oil supplementation.Methods.Male Wistar rats were divided into the following groups: control (C), fructose (F) (water intake with 10% or 30% fructose for 9 weeks), fish oil (FO), and fructose/fish oil (FFO). Fish oil was supplemented only for the last 33 days of fructose ingestion. Half of the F group remained for additional 8 weeks without fructose ingestion (FR).Results.Fructose ingestion reduced food intake to compensate for the increased energy obtained through water ingestion, independent of fructose concentration. Fish oil supplementation exerted no impact on these parameters, but the removal of fructose from water recovered both ingestion behaviors. Plasma triacylglycerol augmented significantly during the second and third weeks (both fructose groups). Fish oil supplementation did not attenuate the elevation in triacylglycerol caused by fructose intake, but the interruption of sugar consumption normalized this parameter.Conclusion.Elevation in triacylglyceridemia may be recovered by removing fructose from diet, suggesting that it is never too late to repair improper dietary habits. |
| Databáze: | OpenAIRE |
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