Al2O3 micro- and nanostructures affect vascular cell response
| Autor: | Ayman Haidar, Cagri Kaan Akkan, Juseok Lee, Marina Martinez Miró, Hashim Abdul-Khaliq, E. Akman, Murat Kasap, Dilek Ural, Gurler Akpinar, Michael Veith, Arif Demir, Tuba Ikier, Mehmet Kesmez, Cenk Aktas, E. Kacar, Karin Kiefer |
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| Přispěvatelé: | Ural, Dilek, Kiefer, Karin, Akpınar, Gürler, Haidar, Ayman, Ikier, Tuba, Akkan, Çağrı Kaan, Akman, Erhan, Lee, Juseok, Miro, Marina Martinez, Kaçar, Elif, Demir, Arif, Veith, Michael, Kasap, Murat, Kesmez, Mehmet, Abdul-Khaliq, Hashim, Aktaş, Cenk, School of Medicine, Department of Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Nanostructure
Endothelium Chemistry General Chemical Engineering Nanotechnology 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease Surface-topography Endothelial-cells Adhesion Vimentin Proliferation Nanowires Filaments Stenosis Behavior Growth 01 natural sciences 0104 chemical sciences Cell biology medicine.anatomical_structure Smooth muscle Restenosis medicine Stent implantation Cell response 0210 nano-technology Medicine Cardiology |
| Zdroj: | RSC Advances |
| Popis: | In-stent restenosis (ISR) is one of the most common and serious complications observed after stent implantation. ISR is characterized by the inordinate proliferation of smooth muscle cells (SMC) that leads to narrowing of the blood vessels. To achieve a healthy endothelium, it is critical to selectively enhance the growth of endothelial cells (EC) while suppressing the growth of smooth muscle cells, which is still a major challenge and yet to be achieved. In this study, novel surfaces have been developed to support the selective growth of endothelial cells. Micro-and nanostructured Al2O3 surfaces with unique topographical features were fabricated and tested. Surface characterization and cellular response of endothelial cells (HUVEC) as well as smooth muscle cells (HUVSMC) has been investigated at cellular and molecular levels. A topography driven selective cell response of ECs over SMCs was demonstrated successfully. This selective response of ECs was also analyzed at protein levels in order to understand the basic mechanism. Scientific and Technological Research Council of Turkey (TÜBİTAK); German Federal Ministry of Education and Research (BMBF) |
| Databáze: | OpenAIRE |
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