Candida lusitaniae Breakthrough Fungemia in an Immuno-Compromised Adolescent: Case Report and Review of the Literature
| Autor: | Miriam Antonie Füller, Athanasia Apsemidou, Oliver Kurzai, Evgeny A. Idelevich, Andreas H. Groll, Athanasios Tragiannidis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Echinocandin Candida lusitaniae Case Report Plant Science Disease resistance 03 medical and health sciences fluids and secretions 0302 clinical medicine Epidemiology medicine breakthrough ddc:610 030212 general & internal medicine lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics Fungemia 0303 health sciences biology 030306 microbiology business.industry candidemia bacterial infections and mycoses biology.organism_classification medicine.disease infection Optimal management Transplantation lcsh:Biology (General) Immunology Liposomal amphotericin business transplantation medicine.drug |
| Zdroj: | Journal of Fungi, Vol 6, Iss 380, p 380 (2020) Journal of Fungi |
| ISSN: | 2309-608X |
| DOI: | 10.3390/jof6040380 |
| Popis: | Candida lusitaniae is a rare cause of candidemia that is known for its unique capability to rapidly acquire resistance to amphotericin B. We report the case of an adolescent with grade IV graft-vs.-host disease after hematopoietic cell transplantation who developed catheter-associated C. lusitaniae candidemia while on therapeutic doses of liposomal amphotericin B. We review the epidemiology of C. lusitaniae bloodstream infections in adult and pediatric patients, the development of resistance, and its role in breakthrough candidemia. Appropriate species identification, in vitro susceptibility testing, and source control are pivotal to optimal management of C. lusitaniae candidemia. Initial antifungal therapy may consist of an echinocandin and be guided by in vitro susceptibility and clinical response. |
| Databáze: | OpenAIRE |
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