Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men
| Autor: | Joakim Eriksson, Peter Jönsson, Siv Ahrné, Hans Bolinsson, Gunilla Önning, Caroline Linninge, Gerd Johansson |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cholera Toxin Hypothalamo-Hypophyseal System Time Factors Hydrocortisone Provocation test Physiology Pituitary-Adrenal System Burnout Permeability 03 medical and health sciences Young Adult 0302 clinical medicine Stress Physiological Surveys and Questionnaires Gut permeability Trier social stress test Medicine Humans Intestinal Mucosa Protein Precursors Reactivity (psychology) Saliva Social stress Haptoglobins business.industry Interleukin-6 General Neuroscience Age Factors Zonulin Healthy Volunteers 030227 psychiatry Neuropsychology and Physiological Psychology Psychosocial stress business 030217 neurology & neurosurgery Biomarkers Stress Psychological |
| Zdroj: | Biological psychology. 138 |
| ISSN: | 1873-6246 |
| Popis: | The virtual version of the Trier Social Stress Test (V-TSST) is an effective and standardized tool for social stress induction. This study aimed to examine gut permeability and physiological and inflammatory markers of reactivity to acute psychosocial stress. Forty young men were classified as high-stressed (HIGHS) or low-stressed (LOWS) according to the Shirom-Melamed Burnout Questionnaire. Cardiovascular reactivity and gut dysfunction were studied along with cortisol, zonulin and cytokines. Gut permeability was shown to be affected within one hour after the psychosocial stress induction, and shown to be dependent on age. Interleukin-6 increased with time, most pronounced at the end of the one-hour recovery after V-TSST, and was positively correlated to age. HIGHS experienced more abdominal dysfunction compared to LOWS. In conclusion, this study is the first to show fluctuations in gut permeability after psychosocial stress induction. This was partly associated with changes in inflammatory markers. |
| Databáze: | OpenAIRE |
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