Evaluation of mutagenic and antimutagenic activities of oligorutin and oligoesculin
| Autor: | Mohamed Ghoul, Mounira Krifa, Ghada Ben Rhouma, Latifa Chebil, Leila Chekir-Ghedira |
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| Rok vydání: | 2012 |
| Předmět: |
Stereochemistry
Rutin Medicinal chemistry Polymerization Analytical Chemistry Ames test Structure-Activity Relationship chemistry.chemical_compound Animals Structure–activity relationship Trametes versicolor Laccase Bacteria Molecular Structure biology Mutagenicity Tests Antimutagenic Agents General Medicine biology.organism_classification Esculin Rats Monomer chemistry Antimutagen Mutagens Food Science |
| Zdroj: | Food Chemistry. 135:1700-1707 |
| ISSN: | 0308-8146 |
| Popis: | Rutin and esculin have been polymerised by laccase. Five fractions with M(w)¯ between 2127.42 and 8331.85g/mol for oligorutins, and between 688.12 and 6973g/mol for oligoesculins, were obtained. Fourier transformed infrared analysis showed that oligorutins were formed through C-C, C-O and CO linkages, while oligoesculins were obtained through C-C linkages. Monomers, their oligomers and their metabolites exhibited no mutagenic effect. Oligorutins and oligoesculins were more efficient in reducing the mutagenicity of methyl methanesulphonate, by, respectively, 69% and 64.8% in the presence of Salmonella typhimurium TA104, and 79.7% and 68.9% in the presence of S. typhimurium TA102, than were their monomers. The same oligomers revealed greater significant inhibitory effect of 2-aminoanthracene mutagenicity (respectively 82.4% and 79.3% in the presence of S. typhimurium TA104, and 89.2% and 82.9% in the presence of S. typhimurium TA102), than their monomers. Our results strongly suggest the enhancement of the tested monomer antimutagenicity after polymerisation. |
| Databáze: | OpenAIRE |
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