Structural Perspectives on the Mechanism of Soluble Guanylate Cyclase Activation

Autor: Michael A. Marletta, Elizabeth C Wittenborn
Rok vydání: 2021
Předmět:
0301 basic medicine
inorganic chemicals
soluble guanylate cyclase
QH301-705.5
1.1 Normal biological development and functioning
cryo-electron microscopy
Review
Nitric Oxide
Catalysis
Nitric oxide
Inorganic Chemistry
03 medical and health sciences
chemistry.chemical_compound
Soluble Guanylyl Cyclase
nitric oxide
Genetics
Animals
Humans
heterocyclic compounds
Physical and Theoretical Chemistry
Biology (General)
Receptor
Molecular Biology
Cyclic guanosine monophosphate
QD1-999
Cyclic GMP
Spectroscopy
chemistry.chemical_classification
Chemical Physics
030102 biochemistry & molecular biology
Mechanism (biology)
Organic Chemistry
Cryoelectron Microscopy
General Medicine
Enzyme structure
Computer Science Applications
Cell biology
enzyme structure
Chemistry
030104 developmental biology
Enzyme
chemistry
Second messenger system
cardiovascular system
cryo–electron microscopy
Other Biological Sciences
Other Chemical Sciences
Guanylate cyclase
Signal Transduction
Zdroj: International journal of molecular sciences, vol 22, iss 11
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5439, p 5439 (2021)
Popis: The enzyme soluble guanylate cyclase (sGC) is the prototypical nitric oxide (NO) receptor in humans and other higher eukaryotes and is responsible for transducing the initial NO signal to the secondary messenger cyclic guanosine monophosphate (cGMP). Generation of cGMP in turn leads to diverse physiological effects in the cardiopulmonary, vascular, and neurological systems. Given these important downstream effects, sGC has been biochemically characterized in great detail in the four decades since its discovery. Structures of full-length sGC, however, have proven elusive until very recently. In 2019, advances in single particle cryo–electron microscopy (cryo-EM) enabled visualization of full-length sGC for the first time. This review will summarize insights revealed by the structures of sGC in the unactivated and activated states and discuss their implications in the mechanism of sGC activation.
Databáze: OpenAIRE
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