Increasing incidence and improved survival in ANCA-associated vasculitis-a Danish nationwide study
| Autor: | Nicholas Carlson, David Jayne, Per Ivarsen, Hans Dieperink, Christian Torp-Pedersen, Martin Egfjord, Jon Waarst Gregersen, Wladimir Szpirt, Elizabeth Krarup, Mark McClure, Karl Emil Nelveg-Kristensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty Denmark Renal function Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 030204 cardiovascular system & hematology outcomes Antibodies Antineutrophil Cytoplasmic 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus ANCA testing Epidemiology medicine Humans Cumulative incidence Retrospective Studies 030203 arthritis & rheumatology Transplantation business.industry Incidence Incidence (epidemiology) Absolute risk reduction Middle Aged medicine.disease Confidence interval Nephrology incidence Kidney Failure Chronic Female epidemiology business ANCA-associated vasculitis Kidney disease |
| Zdroj: | Nelveg-Kristensen, K E, Szpirt, W, Carlson, N, McClure, M, Jayne, D, Dieperink, H, Gregersen, J W, Krarup, E, Ivarsen, P, Torp-Pedersen, C & Egfjord, M 2022, ' Increasing incidence and improved survival in ANCA-associated vasculitis-a Danish nationwide study ', Nephrology, Dialysis, Transplantation, vol. 37, no. 1, pp. 63–71 . https://doi.org/10.1093/ndt/gfaa303 Nelveg-Kristensen, K E, Szpirt, W, Carlson, N, McClure, M, Jayne, D, Dieperink, H, Gregersen, J W, Krarup, E, Ivarsen, P, Torp-Pedersen, C & Egfjord, M 2022, ' Increasing incidence and improved survival in ANCA-associated vasculitis-a Danish nationwide study ', Nephrology, Dialysis, Transplantation, vol. 37, no. 1, pp. 63-71 . https://doi.org/10.1093/ndt/gfaa303 Nelveg-Kristensen, K E, Szpirt, W, Carlson, N, McClure, M, Jayne, D, Dieperink, H, Gregersen, J W, Krarup, E, Ivarsen, P, Torp-Pedersen, C & Egfjord, M 2022, ' Increasing incidence and improved survival in ANCA-associated vasculitis-a Danish nationwide study ', Nephrology, Dialysis, Transplantation, vol. 37, no. 1, gfaa303, pp. 63-71 . https://doi.org/10.1093/ndt/gfaa303 |
| DOI: | 10.1093/ndt/gfaa303 |
| Popis: | Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) carries a high risk of morbidity and mortality, with outcomes modified by treatment and an incidence that may be increasing. We examined temporal changes in incidence and mortality during 2000–15 using nationwide healthcare registries. Methods Patients with incident AAV were identified using International Classification of Diseases Version 10 (ICD10) codes and grouped according to inclusion year (Period 1: 2000–04, Period 2: 2005–09, Period 3: 2010–15). Log link cumulative incidence regression adjusted for age, sex, renal function, cardiovascular disease, diabetes, hypertension and advanced disease severity were used to model survival. Results We identified 1631 patients (52% male), corresponding to an incidence of 18.5 persons/million/year (Period 1: 15.1, Period 2: 18.5, Period 3: 21.4). The slope of incident serologic ANCA testing was steeper than that of AAV (P = 0.002). Mean [standard deviation (SD)] age was 60.2 (16.7) years and mean (SD) follow-up was 6.8 (4.7) years. A total of 571 (35%) patients died (5-year mortality of 22.1%), with an absolute risk ratio (ARR) for Periods 2 and 3 compared with Period 1 of 0.80 [confidence interval (CI) 0.65–0.98, P = 0.031] and 0.39 (CI 0.31–0.50, P Conclusions Incidence of ANCA testing and AAV diagnosis increased over the test period. Falls over time in mortality and ESRD risk may relate to earlier diagnosis and changes in treatment practice. |
| Databáze: | OpenAIRE |
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