A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation
| Autor: | Nila Patil, Richard M. Myers, David R. Cox, Deepti Bhat, Andrew S. Peterson, Malek Faham |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Potassium Channels
Membrane permeability Cell division Chromosomes Human Pair 21 Cellular differentiation Molecular Sequence Data Synaptogenesis Gene Expression Biology Polymerase Chain Reaction Protein Structure Secondary Mice Mice Neurologic Mutants GTP-Binding Proteins Cerebellum Genetics medicine Animals Humans Point Mutation Missense mutation Amino Acid Sequence Potassium Channels Inwardly Rectifying Crosses Genetic DNA Primers Sequence Deletion Neurons Polymorphism Genetic Base Sequence Sequence Homology Amino Acid Inward-rectifier potassium ion channel Homozygote Chromosome Mapping Cell Differentiation Granule cell Potassium channel Cell biology Mice Inbred C57BL Muridae Meiosis medicine.anatomical_structure G Protein-Coupled Inwardly-Rectifying Potassium Channels |
| Zdroj: | Nature Genetics. 11:126-129 |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | Early events in neuronal differentiation are generally considered to be regulated by factors independent of alterations in membrane permeability. Weaver mice harbour a mutation that blocks neuronal differentiation just after cessation of cell division, prior to cell migration and synaptogenesis. Cerebellar granule cells in homozygous weaver mice fail to differentiate, either because intrinsic cues are absent or because the granule cells are unable to respond to those cues. We now report that weaver mice have a missense mutation in a gene encoding a G-protein coupled inward rectifier potassium channel. The mutation alters the putative ion-permeable, pore-forming domain of the protein, suggesting that granule cell differentiation is regulated by changes in membrane permeability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|