Total serum IgE and outcome in infants with recurrent wheezing
| Autor: | Luigi Gagliardi, S. Sideri, G U Cislaghi, Maria Francesca Patria, Franca Rusconi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Allergy Pediatrics medicine.medical_specialty Immunoglobulin E Atopy Predictive Value of Tests Medicine Humans Respiratory sounds Prospective Studies Prospective cohort study Child Asthma Respiratory Sounds Skin Tests biology medicine.diagnostic_test business.industry Age Factors Infant medicine.disease Prognosis General and Acute Paediatrics El Niño Predictive value of tests Child Preschool Pediatrics Perinatology and Child Health biology.protein Female business Biomarkers |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1468-2044 |
| Popis: | OBJECTIVETo investigate the relation between total serum IgE at 0.5–3 and 3–6 years, and the risk of allergic sensitisation and persistent wheezing up to 8 years of age.METHODSProspective follow up study of 45 infants with highly recurrent wheezing, no allergic symptoms, and negative skin tests.RESULTSIn the last follow up year, 15 children still suffered from wheezing. Five wheeze-free and four episodically wheezing children had become sensitised. No association was found between early (0.5–3 years) IgE z scores and the recurrence of wheezing during follow up, or atopic sensitisation. IgE z scores at 3–6 years were significantly higher in children with positive skin tests (p = 0.013), but were still not associated with recurrence of wheezing.CONCLUSIONSIn subjects with frequent early wheezing and no signs of atopy, early total serum IgE measurements are not predictive of outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|