The modulation of striatal dopamine release correlates with water-maze performance in aged rats
| Autor: | Hayat Harati, Monique Majchrzak, Rolf Jackisch, Veronika Siedschlag, Alexandra Barbelivien, Thomas J. Feuerstein, Susanne Rutz, Jean-Christophe Cassel, Anna Katharina Rothmaier |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Aging medicine.drug_class Dopamine Striatum Water maze chemistry.chemical_compound Dopamine receptor D2 Internal medicine Task Performance and Analysis medicine Animals Rats Long-Evans Neurotransmitter Maze Learning General Neuroscience Dopaminergic Receptor antagonist Adaptation Physiological Corpus Striatum Rats Endocrinology chemistry Receptors Serotonin Mental Recall Female Neurology (clinical) Geriatrics and Gerontology Sulpiride Developmental Biology medicine.drug |
| Zdroj: | Neurobiology of aging. 30(6) |
| ISSN: | 1558-1497 |
| Popis: | Cluster analysis of performance during acquisition of a place-learning task in the water maze distinguished between subpopulations of aged rats (25-27 months) classified as moderately (AMI) or severely impaired (ASI) in comparison with young adults (3-5 months). Using a slice-superfusion device, electrically or nicotine-evoked release of dopamine from striatum was assessed in the presence of GR-55,562 (5-HT(1B) receptor antagonist), methiotepin (mixed 5-HT(1/2) receptor antagonist) and/or sulpiride (D(2)/D(3) receptor antagonist). The main neuropharmacological results demonstrated age-related alterations in the 5-HT(1B)- and D(2)/D(3)-mediated modulation of electrically evoked striatal dopamine release. Regression analyses indicated a possible contribution of such alterations to the age-related behavioural deficits: the larger the deficit, the weaker the electrically evoked release under 5-HT(1B) and D(2)/D(3) receptor blockade. Extending our recent report on the modulation of striatal acetylcholine release in aged rats [Cassel et al., 2007. Neurobiol. Aging 28, 1270-1285], these new findings make dopaminergic and serotonergic functional alterations potential candidates to participate in age-related deficits in the water maze, most probably in interaction with formerly described cholinergic dysfunctions. |
| Databáze: | OpenAIRE |
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