The usefulness of serum thyroglobulin in the follow-up of differentiated thyroid carcinoma in children
| Autor: | Catherine Mort, R. Touzel, Jeremy M. W. Kirk, Nicholas Plowman, David B. Grant |
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| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system Cancer Research medicine.medical_specialty Pathology endocrine system diseases Adolescent medicine.medical_treatment Adenocarcinoma Asymptomatic Gastroenterology Sensitivity and Specificity Thyroglobulin Thyroid carcinoma Recurrence Internal medicine medicine Carcinoma Biomarkers Tumor Humans False Positive Reactions Thyroid Neoplasms Neoplasm Metastasis Child Lymph node Thyroglobulin Measurement business.industry Thyroid Cancer medicine.disease Carcinoma Papillary medicine.anatomical_structure Oncology Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Medical and pediatric oncology. 20(3) |
| ISSN: | 0098-1532 |
| Popis: | Serum thyroglobulin has been measured serially in ten children aged 5-17 years presenting with differentiated thyroid carcinoma. At presentation 4 had intra-thyroidal disease, 3 had lymph node metastases, and 3 had lung metastases. During follow-up for a median of 37.0 months (range 21-108) 3 patients have been disease-free, 4 have had a local relapse, and 3 have had persistent disease. Seventy-seven separate serum thyroglobulin measurements have been performed; 36 on and 41 off thyroid replacement therapy. A level of thyroglobulin of less than 5 ng/ml was taken as indicative of absence of disease, and compared against combined clinical examination and 131I scanning. Overall sensitivity of thyroglobulin measurement was 36/37 (97%), and although specificity was 30/40 (75%), this rose to 30/32 (94%) if raised thyroglobulin levels noted within 3 months of 131I therapy in otherwise asymptomatic patients (n = 4) or in subjects with intact thyroid tissue (n = 4) were excluded. Concordance with clinical status was 30/31 (97%) in measurements taken on, and 31/32 (94%) in those taken off, thyroid replacement. These data indicate that thyroglobulin measurement is a sensitive and specific means of detecting residual, recurrent, and metastatic thyroid carcinoma in children. |
| Databáze: | OpenAIRE |
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