A trial of flunarizine in the treatment of Duchenne muscular dystrophy
| Autor: | David J. Dick, David Gardner‐medwin, Timothy J. Walls, Peter G. Gates, Judy M. Simpson, Mary Gibson |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Vital capacity Adolescent Physiology Duchenne muscular dystrophy Muscular Dystrophies law.invention Cinnarizine Cellular and Molecular Neuroscience Randomized controlled trial Double-Blind Method law Physiology (medical) medicine Animals Humans Functional ability Child Flunarizine Muscle contracture Clinical Trials as Topic business.industry Antagonist Syndrome medicine.disease Calcium Channel Blockers Rats El Niño Anesthesia Physical therapy Neurology (clinical) business medicine.drug |
| Zdroj: | Musclenerve. 9(4) |
| ISSN: | 0148-639X |
| Popis: | Twenty-seven boys with Duchenne muscular dystrophy (DMD) entered a double-blind controlled trial of treatment with the calcium antagonist flunarizine. They were matched for age and disability. At monthly intervals, muscle power, functional ability, locomotor score, contractures, and forced vital capacity were measured by a team not involved in clinical care. Over a period of 1 year, flunarizine in a dose of up to 0.25 mg/kg/day had no effect on the clinical course of the disease. |
| Databáze: | OpenAIRE |
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