Two-dimensional speckle-tracking strain echocardiography in long-term heart transplant patients: a study comparing deformation parameters and ejection fraction derived from echocardiography and multislice computed tomography
| Autor: | Stephane Mahr, Andreas Zuckermann, Peter Höfer, Jutta Bergler-Klein, Thomas Binder, Susanne Roedler, Markus Vertesich, Georg Goliasch, Philipp Pichler, Bonni Syeda |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Systole Heart Ventricles medicine.medical_treatment Statistics as Topic Population Coronary Artery Disease Coronary Angiography Ventricular Function Left Body Mass Index Coronary artery disease Ventricular Dysfunction Left Internal medicine medicine Health Status Indicators Humans Radiology Nuclear Medicine and imaging Multislice Prospective Studies education Heart transplantation education.field_of_study Chi-Square Distribution Ejection fraction Tomography X-Ray business.industry Stroke Volume General Medicine Stroke volume Middle Aged medicine.disease Transplantation Echocardiography Case-Control Studies Cardiology Heart Transplantation Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Echocardiography. 12:490-496 |
| ISSN: | 1532-2114 1525-2167 |
| Popis: | Aims Longitudinal strain determined by speckle tracking is a sensitive parameter to detect systolic left ventricular dysfunction. In this study, we assessed regional and global longitudinal strain values in long-term heart transplants and compared deformation indices with ejection fraction as determined by transthoracic echocardiography (TTE) and multislice computed tomographic coronary angiography (MSCTA). Methods and results TTE and MSCTA were prospectively performed in 31 transplant patients (10.6 years post-transplantation) and in 42 control subjects. Grey-scale apical views were recorded for speckle tracking (EchoPAC 7.0, GE) of the 16 segments of the left ventricle. The presence of coronary artery disease (CAD) was assessed by MSCTA. Strain analysis was performed in 1168 segments [496 in transplant patients (42.5%), 672 in control subjects (57.7%)]. Global longitudinal peak systolic strain was significantly lower in the transplant recipients than in the healthy population (−13.9 ± 4.2 vs. −17.4 ± 5.8%, P < 0.01). This was still the case after exclusion of the nine transplant patients with CAD (−14.1 ± 4.4 vs. −17.4 ± 5.8%, P =0.03). Transplant patients exhibited significantly lower regional strain values in 9 of the 16 segments. Left ventricular ejection fraction (%) (MSCTA/Simpsons method) was 60.7 ± 10.1%/60.2 ± 6.7% in transplant recipients vs. 64.7 ± 6.4%/63.0 ± 6.2% in the healthy population, P =ns. Conclusion Even though ‘healthy’ heart transplants without CAD exhibit normal ejection fraction, deformation indices are reduced in this population when compared with control subjects. Our findings suggests that strain analysis is more sensitive than assessment of ejection fraction for the detection of abnormalities of systolic function. |
| Databáze: | OpenAIRE |
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