Rubella Virus E2 Signal Peptide Is Required for Perinuclear Localization of Capsid Protein and Virus Assembly
| Autor: | Tom C. Hobman, Ali Esmaili, Lok Man J. Law, Hira L. Nakhasi, Robert Duncan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Signal peptide
viruses Immunology Biology Protein Sorting Signals medicine.disease_cause Transfection Microbiology symbols.namesake Capsid Viral Envelope Proteins Virology medicine Animals Signal peptidase Endoplasmic reticulum Structure and Assembly Virus Assembly Rubella virus Golgi apparatus Group-specific antigen biochemical phenomena metabolism and nutrition Molecular biology Transport protein Protein Transport Insect Science COS Cells symbols |
| Popis: | The rubella virus (RV) structural proteins capsid, E2, and E1 are synthesized as a polyprotein precursor. The signal peptide that initiates translocation of E2 into the lumen of the endoplasmic reticulum remains attached to the carboxy terminus of the capsid protein after cleavage by signal peptidase. Among togaviruses, this feature is unique to RV. The E2 signal peptide has previously been shown to function as a membrane anchor for the capsid protein. In the present study, we demonstrate that this domain is required for RV glycoprotein-dependent localization of the capsid protein to the juxtanuclear region and subsequent virus assembly at the Golgi complex. |
| Databáze: | OpenAIRE |
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