The effect of serotonin on in vitro insulin secretion and biosynthesis in mice
| Autor: | Ernst-Friedrich Pfeiffer, J. J. Gagliardino, C Nierle |
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| Rok vydání: | 1974 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment In Vitro Techniques Tritium Islets of Langerhans Mice chemistry.chemical_compound Biosynthesis Leucine Internal medicine Insulin Secretion Internal Medicine medicine Animals Insulin Amino Acids Insulin secretion Incubation Isolated islets Stimulation Chemical In vitro Culture Media Glucose Monoamine neurotransmitter Endocrinology chemistry Proinsulin |
| Zdroj: | Diabetologia. 10:411-414 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | The effect of serotonin on insulin secretion and biosynthesis was studied using isolated islets of mice. Serotonin produced a small stimulatory effect on insulin secretion when glucose was present in the incubation medium at a low concentration. On the other hand, an inhibition of insulin secretion was obtained with serotonin when glucose in the medium reached 3.0 mg/ml concentration. No significant effect of serotonin was obtained on insulin biosynthesis, neither in the presence of low nor with a high glucose concentration. These results suggest that the effect of this monoamine on insulin secretion is not mediated via its effect on insulin biosynthesis. |
| Databáze: | OpenAIRE |
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