Phase Lag Analyses on Ictal Scalp Electroencephalography May Predict Outcomes of Corpus Callosotomy for Epileptic Spasms
Autor: | Masayoshi Oguri, Tohru Okanishi, Sotaro Kanai, Shimpei Baba, Mitsuyo Nishimura, Kaoru Ogo, Takashi Himoto, Kazuo Okanari, Yoshihiro Maegaki, Hideo Enoki, Ayataka Fujimoto |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Youden's J statistic Electroencephalography Audiology lcsh:RC346-429 Correlation pre-surgical evaluation of epilepsy 03 medical and health sciences 0302 clinical medicine phase lag analysis cross-frequency analysis medicine Corpus callosotomy Ictal lcsh:Neurology. Diseases of the nervous system Original Research medicine.diagnostic_test business.industry epileptic spasms (ES) medicine.disease Epileptic spasms 030104 developmental biology medicine.anatomical_structure electroencephaloagraphy (EEG) Neurology Scalp corpus callosotomy Laterality computer analysis Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology Oguri Masayoshi, Okanishi Tohru, Kanai Sotaro, et al. Phase Lag Analyses on Ictal Scalp Electroencephalography May Predict Outcomes of Corpus Callosotomy for Epileptic Spasms. FRONTIERS IN NEUROLOGY. 2020. 11. doi:10.3389/fneur.2020.576087 |
ISSN: | 1664-2295 |
Popis: | Objective: We aimed to clarify the patterns of ictal power and phase lag among bilateral hemispheres on scalp electroencephalography (EEG) recorded pre-operatively during epileptic spasms (ESs) and the correlation with the outcomes following corpus callosotomy.Methods: We enrolled 17 patients who underwent corpus callosotomy for ESs before 20 years of age. After corpus callosotomy, seven patients did not experience further ESs (favorable outcome group), and the remaining 10 patients had ongoing ESs (unfavorable outcome group). We used pre-operative scalp EEG data from monopolar montages using the average reference. The relative power spectrum (PS), ictal power laterality (IPL) among the hemispheres, and phase lag, calculated by the cross-power spectrum (CPS) among symmetrical electrodes (i.e., F3 and F4), were analyzed in the EEG data of ESs from 143 pre-operative scalp video-EEG records. Analyses were conducted separately in each frequency band from the delta, theta, alpha, beta, and gamma range. We compared the means of those data in each patient between favorable and unfavorable outcome groups.Results: Among all frequency bands, no significant differences were seen in the individual mean relative PSs in the favorable and unfavorable outcome group. Although the mean IPLs in each patient tended to be high in the unfavorable outcome group, no significant differences were found. The mean CPSs in the delta, theta, and gamma frequency bands were significantly higher in the unfavorable than in the favorable outcome group. Using the Youden index, the optimal cutoff points of those mean CPS values for unfavorable outcomes were 64.00 in the delta band (sensitivity: 100%, specificity: 80%), 74.20 in the theta band (100, 80%), and 82.05 in the gamma band (100, 80%). Subanalyses indicated that those CPS differences originated from pairs of symmetrical electrodes in the bilateral frontal and temporal areas.Significance: Ictal power and laterality of the ictal power in each frequency band were not associated with the outcomes of CC; however, the phase lags seen in the delta, theta, and gamma frequency bands were larger in the unfavorable than in the favorable outcome group. The phase lags may predict outcomes of CC for ESs on pre-surgical scalp-ictal EEGs. |
Databáze: | OpenAIRE |
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