Severe hemoperitoneum resulting from restart of letrozole after oocyte retrieval procedure: a case report

Autor:	Yosuke Gomi, Kouki Samejima, Yosihisa Ono, Haipeng Huang, Masahiro Saitoh, Tatsuya Narita, Hiroyuki Seki, Yasushi Takai, Sigetaka Matsunaga, Shunichiro Ichinose, Yukiko Itaya
Rok vydání:	2021
Předmět:	Adult Abdominal pain medicine.medical_specialty Ovarian Hemorrhage Oocyte Retrieval Breast Neoplasms Case Report Laparoscopic surgery 03 medical and health sciences 0302 clinical medicine Breast cancer Embryo cryopreservation Ovulation Induction medicine Humans Ovarian hemorrhage 030212 general & internal medicine Hemoperitoneum Fertility preservation Oncofertility 030219 obstetrics & reproductive medicine business.industry Letrozole Fertility Preservation General Medicine medicine.disease Surgery Medicine Female medicine.symptom Neoplasm Recurrence Local business medicine.drug
Zdroj:	Journal of Medical Case Reports Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
ISSN:	1752-1947
Popis:	Background In the field of oncofertility, patients with breast cancer are often administered letrozole as an adjuvant drug before and after oocyte retrieval to prevent an increase in circulating estradiol. Case presentation We report a case of abdominal hemorrhage due to an ovarian rupture in a 29-year-old Japanese patient who restarted letrozole 2 days after an oocyte retrieval procedure in which 14 mature oocytes were retrieved. The patient had sought embryo cryopreservation as a fertility preservation option before undergoing treatment for recurrent breast cancer. A day after restarting letrozole treatment, the patient unexpectedly developed severe abdominal pain. Laparoscopic hemostasis was performed to manage the ovarian swelling and hemorrhage. Conclusions The ovaries can be restimulated by restart letrozole after an oocyte retrieval procedure. Therefore, reproductive-medicine practitioners should understand the potential complications of letrozole administration in such cases and take steps to ensure that they are minimized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb5cb094cdeede6ce23bbbe409b197e https://pubmed.ncbi.nlm.nih.gov/34174941 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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