Pet ownership in pregnancy and methylation pattern in cord blood

Autor:	Grzegorz Myszczyszyn, Tomasz Szmatoła, Hanna Danielewicz, Anna Myszkal, Anna Dębińska, Artur Gurgul, Igor Jasielczuk, Anna Drabik-Chamerska, Lidia Hirnle, Andrzej Boznański
Rok vydání:	2021
Předmět:	Allergy Immunology Mothers Physiology Biology Article Atopy Immune system Pregnancy Immunogenetics Genetics medicine Humans Epigenetics Gene Genetics (clinical) Ownership Glycosyltransferases Methylation DNA Methylation Fetal Blood medicine.disease Cord blood Female Transcription Factors
Zdroj:	Genes and Immunity
ISSN:	1476-5470 1466-4879
DOI:	10.1038/s41435-021-00151-7
Popis:	Having pets in the house during the first years of life has been shown to protect against allergies. However, the result of different studies is heterogeneous. The aim of this study was to evaluate the methylation pattern in cord blood in relation to pet ownership during pregnancy. We investigated the methylation patterns of 96 cord blood samples, participants of the Epigenetic Hallmark of Maternal Atopy and Diet—ELMA project, born to mothers who either owned pets (n = 32) or did not own pets (n = 64) during their pregnancy. DNA from cord blood was analysed using the Infinium methylation EPIC. For statistical analysis, RnBeads software was applied. We found 113 differentially methylated sites (DMs) in the covariate-adjusted analysis (FDR p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb3d1f01877790b0a93ec24cb3aa5e9 https://doi.org/10.1038/s41435-021-00151-7 Zobrazit plný text záznamu Full text from SpringerLink