Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current
| Autor: | Max Johansson, Mikael Bergelin, Johan Bobacka, Jari Viik, Narender Kumar Joon, Atte Kekonen |
|---|---|
| Přispěvatelé: | Tampere University, BioMediTech |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
wound stimulation
Skin impedance hydrogen peroxide 02 engineering and technology sensor array lcsh:Chemical technology multielectrode wound dressing Biochemistry Article Analytical Chemistry 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Sensor array quasi-monopolar bioimpedance Medicine lcsh:TP1-1185 Electrical and Electronic Engineering beneath the dressings Instrumentation integumentary system business.industry Direct current long-term monitoring 217 Medical engineering 021001 nanoscience & nanotechnology Wound monitoring Atomic and Molecular Physics and Optics wound monitoring Intensity (physics) low-intensity direct current Wound area Long term monitoring 0210 nano-technology business Wound healing Biomedical engineering |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 19, Iss 11, p 2505 (2019) Sensors Volume 19 Issue 11 |
| ISSN: | 1424-8220 |
| Popis: | Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2). publishedVersion |
| Databáze: | OpenAIRE |
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