Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers
| Autor: | Cristina Martínez-Ramos, Juan A. Barcia, José Miguel Soria, Ulises Gómez-Pinedo, M. Angeles Garcia Esparza, M. Monleón Pradas |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Scaffold Biocompatibility Traumatic brain injury Neovascularization Physiologic chemistry.chemical_compound Tissue engineering Cell Movement In vivo Neurites medicine Animals Rats Wistar Cryolesion Cerebral Cortex Acrylate Tissue Scaffolds General Neuroscience Endothelial Cells Brain medicine.disease Nerve Regeneration Surgery Acrylates chemistry Astrocytes Brain Injuries Neural tissue regeneration MAQUINAS Y MOTORES TERMICOS Ethyl acrylate Female Angiogenesis Biomedical engineering |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| Popis: | The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury. CMR, JAB, UGP, and MMP acknowledge financing through projects MAT2011-28791-C03-01 and MAT2011-28791-C03-02 and ERA-NET NEURON project PRI-PIMNEU-2011-1372. JMSL acknowledges funding through Programa de Ayudas a la Investigacion Cientifica Universidad CEU-Cardenal Herrera (PRCEU-UCH 34/12, PRCEU-UCH 38/10) and Programa CEU-Santader ayudas a grupos consolidados 2014-2015. |
| Databáze: | OpenAIRE |
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