Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models

Autor: Mamoru Arakawa, Eisuke Tatsumi, Akihide Umeki, Yoshiaki Takewa, Masahiko Ando, Toshihide Mizuno, Minoru Ono, Shunei Kyo, Tomonori Tsukiya, Yoshiyuki Taenaka, Takashi Nishimura, Yuichiro Kishimoto
Rok vydání: 2013
Předmět:
Zdroj: Journal of Artificial Organs. 16:119-128
ISSN: 1619-0904
1434-7229
Popis: Aiming the ‘Bridge to Recovery’ course, we have developed a novel left ventricular assist device (LVAD) controlling system. It can change the rotational speed of the continuous flow LVAD, EVAHEART, synchronized with the cardiac beat. Employing this system, we have already demonstrated that myocardial oxygen consumption (MVO2), which is considered to be equivalent to native heart load, changes in the hearts of normal goats. Herein, we examined changes in goats with acute ischemic heart failure. We studied 14 goats (56.1 ± 6.9 kg) with acute ischemic heart failure due to coronary microsphere embolization. We installed the EVAHEART and drive in four modes: “circuit-clamp”, “continuous support”, “counter-pulse”, and “co-pulse”, with 50 and 100 % bypass. In comparison to the circuit-clamp mode, MVO2 was reduced to 70.4 ± 17.9 % in the counter-pulse mode and increased to 90.3 ± 14.5 % in the co-pulse mode, whereas it was 80.0 ± 14.5 % in the continuous mode, with 100 % bypass (p
Databáze: OpenAIRE
Externí odkaz: