Betaine (Trimethylglycine) as a nutritional agent prevents oxidative stress after chronic ethanol consumption in pancreatic tissue of rats
| Autor: | Güngör Kanbak, Ali Dokumacioglu, Mine Inal, Aysegul Tektas, Kazim Kartkaya |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Xanthine Oxidase medicine.medical_specialty Adenosine Deaminase Endocrinology Diabetes and Metabolism Medicine (miscellaneous) medicine.disease_cause Antioxidants Superoxide dismutase chemistry.chemical_compound Betaine Malondialdehyde Internal medicine medicine Animals Rats Wistar Xanthine oxidase Pancreas Nutrition and Dietetics Ethanol Methionine biology Superoxide Dismutase General Medicine Rats Oxidative Stress Endocrinology chemistry Biochemistry Dietary Supplements biology.protein Trimethylglycine Oxidative stress |
| Zdroj: | International Journal for Vitamin and Nutrition Research. 79:79-86 |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831.79.2.79 |
| Popis: | In this study, we investigated the free radical-mediated cytotoxic effects of chronic ethanol consumption on the pancreatic tissue and a possible cytoprotective effect of betaine as a methyl donor and an important participant in the methionine cycle. Twenty-four male Wistar rats were divided into control, ethanol, and ethanol+betaine groups. Prior to sacrifice, all groups were fed 60 mL/diet per day for two months. Rats in the ethanol group were fed with ethanol 8 g/kg/day. The ethanol+betaine groups were fed ethanol plus betaine (0.5 % w/v). Malondialdehyde levels and adenosine deaminase, superoxide dismutase, and xanthine oxidase activities were determined in pancreatic tissues of rats. Compared to control group, MDA levels increased significantly in the ethanol group (p |
| Databáze: | OpenAIRE |
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