The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients

Autor:	Mona Aslani, Arman Ahmadzadeh, Saiedeh Omidian, Zahra Rezaieyazdi, Abbas Mirshafiey, Seyed Shahabeddin Mortazavi-Jahromi
Rok vydání:	2020
Předmět:	0301 basic medicine Drug Adult Male Adolescent media_common.quotation_subject Immunology Context (language use) Toxicology Proinflammatory cytokine Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine medicine Immunology and Allergy Humans Transcription factor media_common Aged Pharmacology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Hexuronic Acids Anti-Inflammatory Agents Non-Steroidal Intracellular Signaling Peptides and Proteins NF-kappa B IRAK1 NF-κB General Medicine Middle Aged medicine.disease Clinical trial MicroRNAs 030104 developmental biology Interleukin-1 Receptor-Associated Kinases Treatment Outcome chemistry 030220 oncology & carcinogenesis Rheumatoid arthritis Cancer research Cytokines Female business
Zdroj:	Immunopharmacology and immunotoxicology. 42(3)
ISSN:	1532-2513
Popis:	Context: miR-146a, its targets (IRAK1, TRAF6) and NF-κB transcription factor play a fundamental role in rheumatoid arthritis (RA). Positive effects of drug β-d-mannuronic acid (M2000) were proven o...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faae775bda35a80027601c174605b15 https://pubmed.ncbi.nlm.nih.gov/32223462 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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