Structure and expression of ovine complement receptor type 2
| Autor: | Wayne R. Hein, K Yamaguchi, Wendy L. Marston, Lisbeth Dudler, Alan J. Young |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Gene isoform
Sheep General Veterinary Complement component 2 CD46 Immunoprecipitation Immunology B-Lymphocyte Subsets Protein primary structure Gene Expression Regulation Developmental chemical and pharmacologic phenomena DNA Complement receptor Biology Precipitin Tests Complement factor B Molecular biology Sequence Analysis Protein Cytoplasm Animals Protein Isoforms Receptors Complement 3d Cloning Molecular |
| Zdroj: | Veterinary Immunology and Immunopathology. 72:67-72 |
| ISSN: | 0165-2427 |
| DOI: | 10.1016/s0165-2427(99)00112-9 |
| Popis: | The structure of sheep complement receptor type 2 (CR2) was characterised by cDNA cloning, protein sequencing and immunoprecipitation. The primary structure of sheep CR2 is similar to known mammalian homologues but the higher-order structure is unusual. Two distinct CR2 isoforms occur, one of which is ubiquitinated in the cytoplasmic domain, and the two molecular forms are expressed at the cell surface as non-covalently associated dimers. The percentage of sheep B-cells that express CR2 changes during development and varies between different body compartments. CR2 + and CR2 − B-cell subsets also differ in the expression of other surface markers and in functional properties. Differential expression of CR2 may, therefore, delineate B-cells that arose by alternative developmental pathways, or it could be a marker for B-cells at different phases of antigen exposure. |
| Databáze: | OpenAIRE |
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