Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
| Autor: | Syafiq Asnawi Zainal Abidin, Sareshma Sudhesh Dev, Reyhaneh Farghadani, Rakesh Naidu, Iekhsan Othman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
signaling pathway
MAPK/ERK pathway medicine.drug_class RM1-950 Review Receptor tyrosine kinase Tyrosine-kinase inhibitor stat combination therapy chemistry.chemical_compound tyrosine kinase inhibitor medicine curcumin Pharmacology (medical) Protein kinase B PI3K/AKT/mTOR pathway Pharmacology biology polyphenol chemistry receptor tyrosine kinase Cancer research biology.protein Curcumin Therapeutics. Pharmacology Signal transduction |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 12 (2021) |
| ISSN: | 1663-9812 |
| Popis: | Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. The use of small molecule RTK inhibitors however, has been crippled by the emergence of resistance, highlighting the need for a pleiotropic anti-cancer agent that can replace or be used in combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive therapeutic agent mainly due to its potent anti-cancer effects, extensive range of targets and minimal toxicity. Out of the numerous documented targets of curcumin, RTKs appear to be one of the main nodes of curcumin-mediated inhibition. Many studies have found that curcumin influences RTK activation and their downstream signaling pathways resulting in increased apoptosis, decreased proliferation and decreased migration in cancer both in vitro and in vivo. This review focused on how curcumin exhibits anti-cancer effects through inhibition of RTKs and downstream signaling pathways like the MAPK, PI3K/Akt, JAK/STAT, and NF-κB pathways. Combination studies of curcumin and RTK inhibitors were also analysed with emphasis on their common molecular targets. |
| Databáze: | OpenAIRE |
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