Equilibrium distributions for deleterious genes in large stationary populations
| Autor: | Kenneth Lange, K. Gladstien |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Genetics X Chromosome Covariance matrix Large population Emigration and Immigration Biology medicine.disease Models Biological Muscular Dystrophies Genetics Population Huntington Disease Genes Stationary Populations Mutation medicine Humans Mean vector Female Muscular dystrophy Constant (mathematics) Gene Ecology Evolution Behavior and Systematics Genes Dominant |
| Zdroj: | Theoretical Population Biology. 14:322-328 |
| ISSN: | 0040-5809 |
| DOI: | 10.1016/0040-5809(78)90031-x |
| Popis: | In a large population of constant size, there is a unique equilibrium distribution for every deleterious autosomal dominant or deleterious X-linked gene. The purpose of this paper is to determine the mean vector and covariance matrix for such an equilibrium distribution. The theory of branching processes with immigration provides the framework for our investigation. Autosomal dominants can be treated using single-type branching processes; X-linked genes, using two-type branching processes. Application is made to Huntington's chorea and Becker's muscular dystrophy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|