Effect of lavender essential oil on LPS-stimulated inflammation
| Autor: | Yang Kao Wang, May Hua Liao, Mei Yu Huang, Hsiao Chuan Wen, Yung Sheng Huang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide Down-Regulation Inflammation Biology Pharmacology law.invention Cell Line chemistry.chemical_compound law medicine Oils Volatile Humans Plant Oils HSP70 Heat-Shock Proteins Viability assay Receptor Essential oil Superoxide Monocyte NF-kappa B General Medicine Hsp70 Toll-Like Receptor 4 medicine.anatomical_structure Lavandula Complementary and alternative medicine chemistry Immunology medicine.symptom |
| Zdroj: | The American journal of Chinese medicine. 40(4) |
| ISSN: | 1793-6853 |
| Popis: | Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70. |
| Databáze: | OpenAIRE |
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