Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
| Autor: | Michael I. Garry, Ross C. Langley, Jeffery J. Summers, Aidan Bindoff, Alexander D. Tang, Mark R. Hinder, William Bennett, Samuel J. Bolland, Alison J. Canty, Jessica M Collins, Jennifer Rodger |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Dendritic spine
medicine.medical_treatment Repetitive transcranial magnetic stimulation Biophysics Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry Plasticity Biology behavioral disciplines and activities Mice Neuroplasticity medicine Animals Neuronal Plasticity Subthreshold conduction business.industry General Neuroscience Pyramidal Cells musculoskeletal neural and ocular physiology Bayes Theorem Evoked Potentials Motor Transcranial Magnetic Stimulation Transcranial magnetic stimulation Ageing medicine.anatomical_structure nervous system Brain stimulation Structural synaptic plasticity Synaptic plasticity Motor cortex Neurology (clinical) Intermittent theta burst stimulation business Neuroscience RC321-571 |
| Zdroj: | Brain Stimulation, Vol 14, Iss 6, Pp 1498-1507 (2021) |
| Popis: | BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain. Recent data from mouse models have shown that even at subthreshold intensities (0.12 Tesla), rTMS can drive neuronal and glial plasticity in the motor cortex. However, the physiological mechanisms underlying subthreshold rTMS induced plasticity and whether these are altered with normal ageing are unclear.ObjectiveTo assess the effect of subthreshold rTMS, using the intermittent theta burst stimulation (iTBS) protocol on structural synaptic plasticity in the mouse motor cortex of young and aged mice.MethodsLongitudinal in vivo 2-photon microscopy was used to measure changes to the structural plasticity of pyramidal neuron dendritic spines in the motor cortex following a single train of subthreshold rTMS (in young adult and aged animals) or the same rTMS train administered on 4 consecutive days (in young adult animals only). Data were analysed with Bayesian hierarchical generalized linear regression models and interpreted with the aid of Bayes Factors (BF).ResultsWe found strong evidence (BF>10) that subthreshold rTMS altered the rate of dendritic spine losses and gains, dependent on the number of stimulation sessions and that a single session of subthreshold rTMS was effective in driving structural synaptic plasticity in both young adult and aged mice.ConclusionThese findings provide further evidence that rTMS drives synaptic plasticity in the brain and uncovers structural synaptic plasticity as a key mechanism of subthreshold rTMS induced plasticity. |
| Databáze: | OpenAIRE |
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