Incidence and outcomes of hospital treated acute myocarditis from 2003 to 2015 in Spain
| Autor: | Francisco Javier Elola-Somoza, Juan L. Bonilla-Palomas, José Luis Bernal-Sobrino, Ángel Cequier-Fillat, Francisco Marcos Marín, Cristina Fernández-Pérez, Manuel Anguita-Sánchez, Hector Bueno-Zamora, Martín Ruiz-Ortiz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Myocarditis Clinical Biochemistry Population Comorbidity 030204 cardiovascular system & hematology Rate ratio Biochemistry 03 medical and health sciences symbols.namesake 0302 clinical medicine Risk Factors Internal medicine Epidemiology Medicine Humans 030212 general & internal medicine Poisson regression Hospital Mortality Renal Insufficiency education Aged Heart Failure education.field_of_study business.industry Incidence (epidemiology) Mortality rate Incidence Liver Diseases General Medicine Pneumonia Middle Aged medicine.disease Hospitalization Standardized mortality ratio Spain Acute Disease symbols Female business |
| Zdroj: | European journal of clinical investigationREFERENCES. 51(4) |
| ISSN: | 1365-2362 |
| Popis: | Background There are no data on population-based epidemiological changes in acute myocarditis in Europe. Our aim was to evaluate temporal trends in incidence, clinical features and outcomes of hospital treated acute myocarditis (AM) in Spain from 2003 to 2015. Methods We conducted a retrospective longitudinal study using information of all hospital discharges of the Spanish National Health System. All episodes with a discharge diagnosis of AM from 1 January 2003 to 31 December 2015 were included. The risk-standardized in-hospital mortality ratio (RSMR) was calculated using a multilevel risk-adjustment model developed by the Medicare and Medicaid Services. Temporal trends for in-hospital mortality were modelled using Poisson regression analysis. Results A total of 11 147 episodes of AM were analysed, most of them idiopathic (94.7%). The rate of AM discharges increased along the period, from 13 to 30/million inhabitants/year (2003-2015), and this increase was statistically significant when weighted by age and sex (incidence rate ratio, IRR 1.06, 95% CI 1.04-1.08, P = .001). In-hospital crude mortality rate was 3.1%, diminishing significantly along 2003-2015 (IRR 0.95, 95% CI 0.92-0.99, P = .02). RSMR also significantly diminished along the period (IRR 0.95, 95% CI 0.92-0.99, P = .01). Renal failure (OR 7.03, 5.38-9.18, P = .001), liver disease (OR 4.61, 2.59-8.21, P = .001), pneumonia (OR 4.13, 2.75-6.20, P = .001) and heart failure (OR 1.91, 95% CI 1.47-2.47, P = .001) were the strongest independent factors associated with in-hospital mortality. Conclusions Acute myocarditis is an uncommon entity, although hospital discharges have increased in Spain along the study period. Most of AM were idiopathic. Adjusted mortality was low and seemed to decrease from 2003 to 2015, suggesting an improvement in AM management. |
| Databáze: | OpenAIRE |
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