Effects of u50,488, a selective kappa agonist, on atypical mouse opiate systems
| Autor: | Mary Ann Marrazzi, Jawana Lawhorn, Lori Stack, Daniel L'Abbe, Tiffany Eccles, Janet Mullings-Britton, Venus Graham |
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| Rok vydání: | 1990 |
| Předmět: |
Agonist
medicine.medical_specialty Pyrrolidines medicine.drug_class U-50488 Anorexia Eating Mice Internal medicine mental disorders medicine Animals Opioid peptide Endogenous opioid Analgesics Mice Inbred BALB C Morphine Receptors Opioid kappa General Neuroscience digestive oral and skin physiology 3 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide (trans)-Isomer Rats Inbred Strains Rats Mice Inbred C57BL Endocrinology Opioid Mice Inbred DBA Anorexia nervosa (differential diagnoses) Receptors Opioid Endorphins medicine.symptom μ-opioid receptor Psychology medicine.drug |
| Zdroj: | Brain Research Bulletin. 25:199-201 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(90)90276-6 |
| Popis: | We have proposed that endogenous opioids play a critical role in the etiology of anorexia nervosa, mediating an auto-addiction, and that atypical opioid systems in mice may be representative of those in anorexia nervosa patients, in contrast to normal humans and rats. A biological predisposition to eating disorders may result from these atypical opioid systems. Definition of these systems as atypical is based on their responses to morphine, which are preferential for the mu receptor subtype. Three patterns have been described in four strains of mice: anorexia with hyperactivity (BALB/C and C57BL/J), anorexia without hyperactivity (DBA/J), and a biphasic curve (CF-1). The latter showed anorexia and hyperactivity at high doses but increased food intake without a change in motor activity at low doses. These patterns contrast to the increase in food intake and sedation in typical species, including rats and normal humans. In the present study, U50,488, a selective kappa agonist, increases food intake in all four mouse strains, as previously reported in rats. Thus, these two agonists have opposite effects on the atypical mouse systems, but similar effects on the typical rat system. The typical and atypical opioid systems respond oppositely to morphine but similarly to U50,488. |
| Databáze: | OpenAIRE |
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