A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme
| Autor: | Jan Leppert, Dirk Rades, Jaspar Witteler, Matteo M Bonsanto, Steven E. Schild, Peter Trillenberg |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Newly diagnosed Kaplan-Meier Estimate Resection Young Adult Internal medicine Promoter methylation medicine Humans Aged Aged 80 and over Performance status Radiotherapy business.industry Disease Management General Medicine Middle Aged medicine.disease Prognosis Combined Modality Therapy Radiation therapy Treatment Outcome Female business Glioblastoma |
| Zdroj: | Anticancer research. 41(1) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM In a previous study investigating radiotherapy for newly diagnosed glioblastoma multiforme (GBM), significant or almost significant associations with survival were found for performance status, upfront resection, O6-methylguanine-DNA methyl-transferase (MGMT) promoter methylation and unifocal GBM. This study aimed to create a survival score based on these factors. PATIENTS AND METHODS Most of the 81 patients included received resection of GBM followed by radiochemotherapy (59.4 Gy/33 or 60 Gy/30 fractions). The previously identified predictors of survival were re-evaluated. Factors significantly associated with survival were used for the score. RESULTS All factors were significantly associated with survival. For each factor, 0 points (less favorable survival) or 1 point (more favorable survival) were assigned and added for each patient. Three groups were designed, 0-1 (n=10), 2 (n=21) and 3-4 points (n=50); 12-month survival rates were 0%, 38% and 78% (p |
| Databáze: | OpenAIRE |
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