Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin

Autor: Elisabetta L. Romeo, Fiorella Forte, R. Zingale, Domenico Cucinotta, Giuseppina T. Russo, Angela Alibrandi, N. Gambadoro, Annalisa Giandalia, C. Scarcella, Giuseppa Perdichizzi
Rok vydání: 2015
Předmět:
Male
Diabetic neuropathy
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
Diabetic neuropathy
Type 2 diabetes
Metformin
Homocysteine
Vitamin B12
MTHFR
0302 clinical medicine
Endocrinology
Diabetic Neuropathies
Outpatients
Homocysteine
Aged
80 and over
education.field_of_study
biology
Middle Aged
Prognosis
Metformin
Vitamin B 12
Female
medicine.drug
Adult
medicine.medical_specialty
Hyperhomocysteinemia
Genotype
Population
030209 endocrinology & metabolism
03 medical and health sciences
Folic Acid
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Vitamin B12
education
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
business.industry
nutritional and metabolic diseases
medicine.disease
Cross-Sectional Studies
Diabetes Mellitus
Type 2
Methylenetetrahydrofolate reductase
Mutation
MTHFR
biology.protein
business
030217 neurology & neurosurgery
Dyslipidemia
Follow-Up Studies
Zdroj: Journal of Endocrinological Investigation. 39:305-314
ISSN: 1720-8386
DOI: 10.1007/s40618-015-0365-9
Popis: Hyperhomocysteinemia and vitamin B12 deficiency may be involved in the development of diabetic peripheral neuropathy (DPN). Metformin therapy may reduce vitamin B12 plasma levels, thus contributing to DPN. The purposes of this cross-sectional study were to assess (1) the potential associations of DPN with serum levels of homocysteine (tHcy), B-vitamins, and/or the common methylenetetrahydrofolate reductase (MTHFR) C677T mutation; (2) the influence of chronic treatment with metformin on tHcy and B-vitamins concentrations and, finally, (3) to evaluate whether, by this influence, metformin is a risk factor for DPN in a group of type 2 diabetic outpatients. Our data showed that fasting tHcy, folate, and vitamin B12 levels and the MTHFR C677T genotype distribution were comparable between subjects with (n = 79, 30 %) and without DPN (n = 184, 70 %). Metformin-treated subjects (n = 124, 47 %) showed significantly lower levels of vitamin B12 (P
Databáze: OpenAIRE
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