The ameliorating effects of vitamin E on hepatic antioxidant system and xenobiotic-metabolizing enzymes in fenvalerate-exposed iodine-deficient rats
| Autor: | Pinar Erkekoglu, Belma Kocer-Gumusel, Filiz Hincal, Aydan Caglayan |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Thyroid Hormones Antioxidant Thiobarbituric acid Health Toxicology and Mutagenesis medicine.medical_treatment Toxicology Antioxidants Xenobiotics 03 medical and health sciences chemistry.chemical_compound Internal medicine Nitriles Pyrethrins medicine Animals Vitamin E Rats Wistar Pharmacology Fenvalerate Chemical Health and Safety 030102 biochemistry & molecular biology biology Maintenance dose Public Health Environmental and Occupational Health Cytochrome P450 General Medicine Glutathione Endocrinology chemistry Liver Inactivation Metabolic biology.protein Hormone Iodine |
| Zdroj: | Drug and chemical toxicology. 39(3) |
| ISSN: | 1525-6014 |
| Popis: | This study investigated the effects of vitamin E (VE) on hepatic antioxidant system and drug-metabolizing enzymes in fenvalerate (FEN)-exposed iodine-deficient (ID) Wistar rats. ID was produced by perchlorate containing drinking water. VE was introduced by a loading dose of 100 mg/kg/d, i.g. for the first three days in the last week of feeding period; then with a single maintenance dose of 40 mg/kg on the 4th day. During last week, FEN groups (F) received 100 mg/kg/d, i.p. FEN. VE alone did not significantly affect thyroid hormones and antioxidant parameters; however, significantly increased total cytochrome P450 (38%) and cytochrome b5 levels (36%). In all ID groups, plasma thyroid-stimulating hormone (TSH) levels increased markedly, but remained at control level in vitamin E plus FEN receiving iodine-deficient group (IDVF) group. Glutathione peroxidase activity showed marked increases in F (19%) and FEN-exposed iodine-deficient group (IDF, 48%) groups. FEN treatment significantly increased total cytochrome P450 (28%) and thiobarbituric acid reactive substance levels (36%), as well as 7-ethoxyresorufin O-deethylase (120%), 7-penthoxyresorufin O-deethylase (139%) and glutathione S-transferase (15%) activities and decreased total glutathione concentrations (28%) versus control. Overall results suggest that vitamin E has ameliorating effects on the measured parameters in ID and/or FEN exposure. |
| Databáze: | OpenAIRE |
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