Effects of Exposure of Animals to Oxygen Atmosphere at Low Pressure on Lipid Peroxidation and Antioxidant Defense
| Autor: | L A Dzikovskaya, O S Izmest'eva, N I Ryabchenko, L P Zhavoronkov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Antioxidant Cations Divalent medicine.medical_treatment Iron 01 natural sciences Oxygen atmosphere General Biochemistry Genetics and Molecular Biology Antioxidants 010305 fluids & plasmas Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Blood serum Internal medicine Malondialdehyde 0103 physical sciences medicine Animals Rats Wistar Hypoxia Liposome 030102 biochemistry & molecular biology General Medicine Oxygenation Rats Oxygen Endocrinology chemistry Free radical oxidation Liposomes Biological Assay Lipid Peroxidation |
| Zdroj: | Bulletin of experimental biology and medicine. 165(5) |
| ISSN: | 1573-8221 |
| Popis: | Relatively short-term (2.5 or 5 h) exposure of Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) resulted in an increase in LPO level and reduction of antioxidant activity in the blood serum. An increase in malondialdehyde concentration 1 day after termination of the exposure was followed by a decrease in the inhibiting activity of free radical oxidation of liposomal phospholipids induced by Fe(II) ions (100 μm). Malondialdehyde concentration increased by 1.29 times already after 2.5-h exposure and did not changed when the duration of the exposure to oxygen atmosphere was prolonged to 5 h. These data confirm the necessity of using substances potentiating antioxidant defense of the body during exposure to normobaric oxygenation. |
| Databáze: | OpenAIRE |
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