Action of dibenzofurans and naphthalenes on intestinal solute transport and fluid transfer in mice
| Autor: | David S. Madge |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Brush border Naphthalenes Intestinal absorption Mice chemistry.chemical_compound Intestine Small Hydrocarbons Chlorinated medicine Animals Amino Acids Benzofurans Pharmacology Chromatography Galactose Maltose medicine.disease Small intestine Dibenzofuran Glucose Polychlorinated terphenyls medicine.anatomical_structure Intestinal Absorption chemistry Biochemistry Glucose-galactose malabsorption Female Mannose |
| Zdroj: | General Pharmacology: The Vascular System. 9:361-367 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(78)90076-9 |
| Popis: | 1. Investigations were made on the effects of a single, oral dose of purified chlorinated dibenzofuran and non-chlorinated dibenzofuran and polychlorinated naphthalenes on in vitro absorption of various solutes and concomitant fluid transfer in the mouse everted small intestine. 2. Absorption of d -glucose decreased 7 days after treatment with each of these chemicals, as did the final d -glucose content of tissue homogenates. d -glucose absorption following membrane hydrolysis of d -maltose was unaltered. d -glucose malabsorption was abolished by an exogenous energy supply ( d -mannose). Intestinal absorption of d -galactose and several amino acids was unchanged. Fluid transfer remained unaltered with each of the solutes. 3. Lowered d -glucose absorption in the experimental animals probably resulted from increased intracellular metabolic effects following absorption and not from impaired function of the d -glucose carrier at the brush border membrane. 4. The apparent malabsorptive effects of d -glucose was both time-dependent and dose-dependent. Dibenzofurans were effective at considerably lower doses compared with naphthalenes. 5. Apparent malabsorption was unrelated to the chlorine content of the chemicals. 6. Histological changes of the small intestine were small and inconsistent; the fresh intestinal weight remained unchanged. 7. The apparent malabsorptive effects of d -glucose using commercial polychlorinated biphenyls and polychlorinated terphenyls were probably caused by traces of toxic chemicals. particularly dibenzofuran, in these compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|