Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6 Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells
| Autor: | Xiaohong Xie, Na Zang, Yun He, Xi-qiang Yang, Lijia Wang, Enmei Liu, Yu Deng, Si-min Li |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
viruses
medicine.medical_treatment Respiratory System Immunology Down-Regulation Respiratory Mucosa Respiratory Syncytial Virus Infections Protein Serine-Threonine Kinases Biology Resveratrol Virus Replication Antiviral Agents Dexamethasone Virus Cell Line chemistry.chemical_compound Interferon Ribavirin Stilbenes medicine Humans Immunology and Allergy Toll-like receptor Interleukin-6 Interleukin-8 virus diseases Epithelial Cells Virology Respiratory Syncytial Viruses Adaptor Proteins Vesicular Transport Cytokine Viral replication chemistry TRIF medicine.drug |
| Zdroj: | Inflammation. 35:1392-1401 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-012-9452-7 |
| Popis: | Respiratory syncytial virus (RSV) is the most common pathogen responsible for lower respiratory diseases in children. So far, there is no effective treatment or preventative vaccine available for RSV infection, although ribavirin and dexamethasone are commonly prescribed. Resveratrol has been shown to inhibit the replication of several other viruses, thus the effect of resveratrol on RSV-induced inflammatory mediators in 9HTEo cell cultures was evaluated, and possible mechanisms of action were explored and compared with dexamethasone and ribavirin. Incubation with resveratrol resulted in decreased IL-6 production and partial inhibition of RSV replication. Resveratrol treatment also inhibited virus-induced TIR-domain-containing adapter-inducing interferon-β (TRIF) and TANK binding kinase 1 (TBK1) protein expression. These data demonstrate the ability of resveratrol to inhibit cytokine production by RSV in airway epithelial cells, indicating that it might be a therapeutic agent with both anti-inflammatory and antiviral potential for the treatment of RSV infection. |
| Databáze: | OpenAIRE |
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