Management of Plantar Keratodermas
| Autor: | Frances J.D. Smith, Rebecca M. Porter, Albert A. Bravo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Hyperkeratosis Keratolytic Erythroderma Comorbidity Risk Assessment Severity of Illness Index 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Keratoderma Palmoplantar Medicine Pachyonychia congenita Humans Pain Management skin and connective tissue diseases Keratoderma business.industry Sick Role Disease Management General Medicine medicine.disease Prognosis Dermatology Alternative treatment 030104 developmental biology medicine.anatomical_structure Palmoplantar keratoderma Pachyonychia Congenita Nail (anatomy) Quality of Life Female business |
| Zdroj: | Journal of the American Podiatric Medical Association. 107(5) |
| ISSN: | 1930-8264 |
| Popis: | Plantar keratodermas can arise due to a variety of genetically inherited mutations. The need to distinguish between different plantar keratoderma disorders is becoming increasingly apparent because there is evidence that they do not respond identically to treatment. Diagnosis can be aided by observation of other clinical manifestations, such as palmar keratoderma, more widespread hyperkeratosis of the epidermis, hair and nail dystrophies, or erythroderma. However, there are frequent cases of plantar keratoderma that occur in isolation. This review focuses on the rare autosomal dominant keratin disorder pachyonychia congenita, which presents with particularly painful plantar keratoderma for which there is no specific treatment. Typically, patients regularly trim/pare/file/grind their calluses and file/grind/clip their nails. Topical agents, including keratolytics (eg, salicylic acid, urea) and moisturizers, can provide limited benefit by softening the skin. For some patients, retinoids help to thin calluses but may lead to increased pain. This finding has stimulated a drive for alternative treatment options, from gene therapy to alternative nongenetic methods that focus on novel findings regarding the pathogenesis of pachyonychia congenita and the function of the underlying genes. |
| Databáze: | OpenAIRE |
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