Ketamine effects on default mode network activity and vigilance: A randomized, placebo-controlled crossover simultaneous fMRI/EEG study
| Autor: | Andreas Saleh, Florian Lammers, Felix Müller, Peter de Boer, Georg Winterer, Francesco Musso, Markus London, Norman Zacharias |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Electroencephalography EEG-fMRI Multimodal Imaging 0302 clinical medicine Prefrontal cortex Default mode network Research Articles media_common Cerebral Cortex Cross-Over Studies Radiological and Ultrasound Technology medicine.diagnostic_test 05 social sciences antidepressant action Magnetic Resonance Imaging Antidepressive Agents Neurology depression Anatomy Function and Dysfunction of the Nervous System Arousal 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit Vigilance (psychology) Research Article Adult ketamine media_common.quotation_subject 050105 experimental psychology 03 medical and health sciences Young Adult Double-Blind Method medicine Connectome Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Resting state fMRI business.industry Default Mode Network EEG‐fMRI Crossover study Brain Waves vigilance control Neurology (clinical) Functional magnetic resonance imaging business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping |
| ISSN: | 1097-0193 |
| Popis: | In resting‐state functional connectivity experiments, a steady state (of consciousness) is commonly supposed. However, recent research has shown that the resting state is a rather dynamic than a steady state. In particular, changes of vigilance appear to play a prominent role. Accordingly, it is critical to assess the state of vigilance when conducting pharmacodynamic studies with resting‐state functional magnetic resonance imaging (fMRI) using drugs that are known to affect vigilance such as (subanesthetic) ketamine. In this study, we sought to clarify whether the previously described ketamine‐induced prefrontal decrease of functional connectivity is related to diminished vigilance as assessed by electroencephalography (EEG). We conducted a randomized, double‐blind, placebo‐controlled crossover study with subanesthetic S‐Ketamine in N = 24 healthy, young subjects by simultaneous acquisition of resting‐state fMRI and EEG data. We conducted seed‐based default mode network functional connectivity and EEG power spectrum analyses. After ketamine administration, decreased functional connectivity was found in medial prefrontal cortex whereas increased connectivities were observed in intraparietal cortices. In EEG, a shift of energy to slow (delta, theta) and fast (gamma) wave frequencies was seen in the ketamine condition. Frontal connectivity is negatively related to EEG gamma and theta activity while a positive relationship is found for parietal connectivity and EEG delta power. Our results suggest a direct relationship between ketamine‐induced functional connectivity changes and the concomitant decrease of vigilance in EEG. The observed functional changes after ketamine administration may serve as surrogate end points and provide a neurophysiological framework, for example, for the antidepressant action of ketamine (trial name: 29JN1556, EudraCT Number: 2009‐012399‐28). |
| Databáze: | OpenAIRE |
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