6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist
Autor: | Christopher B. Naylor, Martyn D. Wood, Ian Thomson Forbes, Frank E. Blaney, Guy A. Kennett, Thomas P. Blackburn, Frank King, Stephen E. Clarke, Steven Mark Bromidge, Kevin M. Thewlis, Malcolm Duckworth, Peter Ham |
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Rok vydání: | 1997 |
Předmět: |
Indoles
Stereochemistry Aminopyridines Chemical synthesis Cell Line chemistry.chemical_compound Drug Discovery Receptor Serotonin 5-HT2C Animals Cytochrome P-450 Enzyme Inhibitors Humans Enzyme Inhibitors Molecular Structure Bicyclic molecule Antagonist Rats 5-HT2C receptor chemistry Blood-Brain Barrier Receptors Serotonin Indoline Molecular Medicine Serotonin Antagonists Penetrant (biochemical) Selectivity SB-242084 |
Zdroj: | Journal of Medicinal Chemistry. 40:3494-3496 |
ISSN: | 1520-4804 0022-2623 |
Databáze: | OpenAIRE |
Externí odkaz: |