Adjuvant activity of saponins from Kazakhstani plants on the immune responses to subunit influenza vaccine
| Autor: | E. S. Omirtaeva, Pavel G. Alexyuk, Andrey Bogoyavlenskiy, Madina Alexyuk, Vladimir Berezin, Aizhan Turmagambetova, Irina A. Zaitseva, Nadezhda S. Sokolova |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Influenza vaccine medicine.medical_treatment Phytochemicals Caryophyllaceae Biology complex mixtures Virus 03 medical and health sciences Subcutaneous injection 0302 clinical medicine Immune system Adjuvants Immunologic Virology medicine Animals Saponaria officinalis 030212 general & internal medicine chemistry.chemical_classification Mice Inbred BALB C General Medicine Saponins biology.organism_classification Kazakhstan carbohydrates (lipids) 030104 developmental biology chemistry Influenza Vaccines Vaccines Subunit Toxicity Influenza A Virus H7N1 Subtype Female Glycoprotein Adjuvant |
| Zdroj: | Archives of Virology. 162:3817-3826 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-017-3560-5 |
| Popis: | In recent years, there have been a number of reports on the successful use of immunostimulatory complexes with saponins and viral glycoproteins as veterinary vaccines and in clinical trials for human medicine. The saponins Algiox, Sapanox and Pangisan were isolated and purified by HPLC from Allochrusa gypsophiloides, Saponaria officinalis and Gypsophila paniculata plants in Kazakhstan and they proved to have low toxicity in experiments with mice, chickens and chicken embryos. Algiox, Sapanox and Pangisan can be used to create immunostimulatory complexes (ISCOMs) similar to saponin-Quil-A-containing ISCOMs both in structure and in immunostimulatory efficiency. The adjuvant effect of the obtained saponins was studied by subcutaneous injection of mice with ISCOMs containing these herbal saponins and lipids and glycoproteins of H7N1 influenza virus. Sapanox, Pangisan and Algiox from Kazakhstani plants of the family Caryophyllaceae could be considered an additional source of highly effective adjuvants not only for veterinary vaccines but also for human medicine. |
| Databáze: | OpenAIRE |
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