Different patterns of NT-proBNP secretion in acute coronary syndromes
| Autor: | Angelo S. Bongo, Chiara Vendramin, Alessandro Lupi, Elia Biganzoli, Simona Ferraro, Lidia Rossi, Patrizia Boracchi, Giuseppe Marano, Giorgio Bellomo, Laura Ciardi |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Acute coronary syndrome Clinical Biochemistry Population Biochemistry chemistry.chemical_compound Internal medicine Natriuretic Peptide Brain medicine Humans Secretion Acute Coronary Syndrome Cystatin C education Aged Aged 80 and over Creatinine education.field_of_study Ejection fraction biology business.industry ST elevation Biochemistry (medical) Age Factors Chromogranin A General Medicine Middle Aged medicine.disease Peptide Fragments Kinetics Endocrinology chemistry biology.protein Female business |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 402(1-2) |
| ISSN: | 1873-3492 |
| Popis: | Background The wide variability of NT-proBNP levels in acute coronary syndromes could arise from sympathetic activation and glomerular impairment. The aim of the study was to investigate, in this setting, the dependence of NT-proBNP from Chromogranin A (CgA) and Cystatin C (CC) levels, respectively assessing sympathetic activation and glomerular impairment. Methods In 132 patients, 90 ST elevation acute coronary syndrome (STE-ACS) and 42 non ST elevation acute coronary syndrome (NSTE-ACS), within 24 h from symptoms and with creatinine levels lower than 141.4 µmol/L, we measured NT-proBNP, CgA and CC levels. In 41 STE-ACS patients we evaluated the kinetic profiles of the markers. Results From the multiple regression model , to investigate the dependence of NT-proBNP from CgA, CC levels, time from symptoms, STE-ACS/NSTE-ACS subsets, gender, adjusting for the effect of left ventricular ejection fraction and age we had evidence of: 1) interactions involving the subsets, the first with CgA levels and the second with age; 2) non linear increasing effect of the delay on NT-proBNP secretion. Conclusions Our data showed that, in the population studied, sympathetic activation and age could affect NT-proBNP secretion yielding different secretory patterns in STE- or NSTE-ACS. Only for STE-ACS we observed higher marker secretion in older patients. |
| Databáze: | OpenAIRE |
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